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PFI-1

CAT: 0013-GTR19172061-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172061-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PFI-1 (PF-6405761) is a potent and selective BET bromodomain inhibitor, exhibiting an IC50 of 0.22 μM against BRD4 in biochemical assays. This cell-permeable compound is a valuable chemical probe for investigating BET protein function in cancer, inflammation, and transcriptional regulation in both cellular and animal models.
CAS Number
1403764-72-6
Product Name Alternative
Apoptosis, Autophagy, BRD2, BRD4, Epigenetic Reader Domain, EpigeneticReaderDomain, Inhibitor, inhibit, PF6405761, PF-6405761, PFI1, PFI-1, PFI 1, PF 6405761
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
97.21% (May vary between batches)
Solubility
DMSO:40 mg/mL (115.14 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.76 mM)
Smiles
COc1ccccc1S (=O) (=O) Nc1ccc2NC (=O) N (C) Cc2c1
Molecular Formula
C16H17N3O4S
Molecular Weight
347.39
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pfi-1

2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide is a member of quinazolines.

CAS Number1403764-72-6
PubChem CID71271629
IUPAC Name2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide
Molecular FormulaC16H17N3O4S
Molecular Weight347.4
XLogP1.2
Topological Polar Surface Area96.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity562
SMILES
CN1CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC=CC=C3OC)NC1=O
InChI
InChI=1S/C16H17N3O4S/c1-19-10-11-9-12(7-8-13(11)17-16(19)20)18-24(21,22)15-6-4-3-5-14(15)23-2/h3-9,18H,10H2,1-2H3,(H,17,20)
InChIKey
TXZPMHLMPKIUGK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pfi-1
CAS: 1403764-72-6
CID: 71271629
Formula: C16H17N3O4S
MW: 347.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight347.4
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass347.09397721
Monoisotopic Mass347.09397721
Topological Polar Surface Area96.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity562
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-16586-01PFI-1
4445/10PFI 1
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A12545-10PFI-1 10mg
A12545-5PFI-1 5mg
C07624-5mgPFI-1 (PF-6405761)
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