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Ipatasertib

CAT: 0013-GTR19172029-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172029-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ipatasertib (GDC-0068) is a potent, ATP-competitive pan-Akt inhibitor with low nanomolar IC50 values against Akt1, Akt2, and Akt3. It induces p53-independent apoptosis by inhibiting Akt to activate FoxO3a and NF-κB, which co-transcribe PUMA, leading to Bax-mediated mitochondrial apoptosis. This mechanism has been investigated in vitro and in vivo for cancer research, particularly in tumors with PTEN deficiency or Akt hyperactivation.
CAS Number
1001264-89-6
Product Name Alternative
GDC-0068; RG7440
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Pan-Akt inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 20 mg/ml)
Smiles
C[C@H]1C2=C (N=CN=C2[C@H] (O) C1) N3CCN (C ([C@H] (CNC (C) C) C4=CC=C (Cl) C=C4) =O) CC3
Molecular Formula
C24H32ClN5O42
Molecular Weight
458.0
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(2S) -2- (4-Chlorophenyl) -1-[4-[ (5R,7R) -7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3- (propan-2-yla, ino) propan-1-one

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