Ipatasertib-NH2 (dihydrochloride)

Ipatasertib-NH2 (dihydrochloride)

• CAS Number: 1001264-73-8
• UNSPSC Description: Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
• Target Antigen: Ligands for Target Protein for PROTAC
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ipatasertib-nh2-dihydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@H]1C2=C(N3CCN(CC3)C([C@@H](C4=CC=C(C=C4)Cl)CN)=O)N=CN=C2[C@@H](C1)O.Cl.Cl
• Molecular Weight: 488.84
• References & Citations: [1]You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported