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Onalespib

CAT: 0013-GTR19171994-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171994-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Onalespib (AT13387) is an orally available small molecule Hsp90 inhibitor with antineoplastic potential. It disrupts Hsp90's chaperone function, leading to the degradation of client oncoproteins critical for tumor survival. This compound has demonstrated activity in preclinical studies across various cancer models, supporting its investigation in oncology research.
CAS Number
912999-49-6
Product Name Alternative
AT 13387, AT13387, AT-13387, Onalespib, Onalespib (AT13387), inhibit, HSP, HSP90, Inhibitor, Heat shock proteins
Field of Research
Metabolism Research, Signal Transduction
Purity
98.05% (May vary between batches)
Solubility
DMSO:2.04 mg/mL (4.98 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM)
Smiles
CC (C) c1cc (C (=O) N2Cc3ccc (CN4CCN (C) CC4) cc3C2) c (O) cc1O
Molecular Formula
C24H31N3O3
Molecular Weight
409.52
References & Citations
Romy Cools # 1, Valeria Narykina # 1 2 3, Koen Vermeulen 4, Sanket J Mishra 5, Brian S J Blagg 5 6, Marleen Derweduwe 7 8 9, Frederik De Smet 7 8 9, Aaron Ziani-Zeryouh 10, Matteo Riva 10 11, An Coosemans 10, Frederic Rousseau 2 3, Joost Schymkowitz 2 3, Guy Bormans 12 [11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics EJNMMI Radiopharm Chem, (2025)
Pubmed id
41003947
Storage Conditions
-20°C
Notes
For research use only.

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