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Onalespib

CAT: 0931-T6284-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T6284-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
912999-49-6
Target
HSP
Related Pathways
Metabolism, Cytoskeletal Signaling
Purity
0.9982
Bioactivity
Onalespib (AT13387) is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.
Smiles
CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O
Molecular Formula
C24H31N3O3
Molecular Weight
409.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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