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AZ960

CAT: 0013-GTR19171969-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171969-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ960 is a potent and selective ATP-competitive inhibitor of JAK2, demonstrating high inhibitory activity with an IC50 of less than 3 nM and a Ki of 0.45 nM. It is a valuable research tool for studying JAK-STAT signaling in hematological malignancies and myeloproliferative disorders, with utility in both in vitro and in vivo experimental models.
CAS Number
905586-69-8
Product Name Alternative
Apoptosis, AZ 960, AZ960, AZ-960, inhibit, JAK, JAK2, Janus kinase, Parasite, Inhibitor, VirusProtease, Virus Protease
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Signal Transduction, Stem Cell & Developmental Biology
Purity
96.02% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:55 mg/mL (155.21 mM) ; Ethanol:3 mg/mL (8.47 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.64 mM)
Smiles
C[C@H] (Nc1nc (Nc2cc (C) [nH]n2) c (F) cc1C#N) c1ccc (F) cc1
Molecular Formula
C18H16F2N6
Molecular Weight
354.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AZ-960
CAS Number905586-69-8
PubChem CID25099184
IUPAC Name5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile
Molecular FormulaC18H16F2N6
Molecular Weight354.4
XLogP4.4
Topological Polar Surface Area89.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity503
SMILES
CC1=CC(=NN1)NC2=C(C=C(C(=N2)N[C@@H](C)C3=CC=C(C=C3)F)C#N)F
InChI
InChI=1S/C18H16F2N6/c1-10-7-16(26-25-10)23-18-15(20)8-13(9-21)17(24-18)22-11(2)12-3-5-14(19)6-4-12/h3-8,11H,1-2H3,(H3,22,23,24,25,26)/t11-/m0/s1
InChIKey
SUNXHXDJOIXABJ-NSHDSACASA-N
Chemical Structure
2D Structure
2D structure of AZ-960
CAS: 905586-69-8
CID: 25099184
Formula: C18H16F2N6
MW: 354.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight354.4
XLogP34.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass354.14045086
Monoisotopic Mass354.14045086
Topological Polar Surface Area89.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity503
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M16510-01AZ960

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