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Zosuquidar trihydrochloride

CAT: 0013-GTR19171823-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171823-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent, third-generation P-glycoprotein (P-gp) inhibitor with a Ki of 60 nM, developed to reverse multidrug resistance in cancer. It has been widely used in both in vitro and in vivo research to investigate chemosensitization and the pharmacokinetic enhancement of co-administered anticancer agents.
CAS Number
167465-36-3
Product Name Alternative
2780, 2780AD, ABCB1, acute myelogenous leukemia, AML, anti-tumor activity, CCRF-CEM, Cluster of differentiation 243, CD243, CEM/VLB100, Inhibitor, HL60, MCF7/ADR, MCF7, MDR1, LY335979, LY-335979, LY335979 Trihydrochloride, LY-335979 Trihydrochloride, LY-335979 trihydrochloride, LY 335979, LY 335979 Trihydrochloride, K562, inhibit, Multidrug resistance protein 1, UCLA-P3, UCLA-P3.003VLB, Zosuquidar, Zosuquidar (LY335979), Zosuquidar (LY335979) 3HCl, Zosuquidar 3HCl, Zosuquidar Trihydrochloride, Zosuquidar trihydrochloride, RS 33295-198, RS 33295-198 (D06387), RS 33295-198 (D06387) 3HCl, RS 33295-198 trihydrochloride, RS 33295-198 Trihydrochloride, P388, P388/ADR, P-gp (P-glycoprotein), Pgp, P-gp, P-glycoprotein
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.49% (May vary between batches)
Solubility
DMSO:80.83 mg/mL (126.89 mM)
Smiles
FC1 ([C@@]2 ([H]) [C@]1 ([H]) C3=CC=CC=C3[C@H] (N4CCN (CC4) C[C@@H] (O) COC5=CC=CC6=C5C=CC=N6) C7=CC=CC=C72) F.Cl.Cl.Cl
Molecular Formula
C32H31F2N3O2·3HCl
Molecular Weight
636.99
Storage Conditions
-20°C
Notes
For research use only.

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