Andrographolide

CAT: 0013-GTR19172046-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19172046-01Size:100 mg

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Description

Andrographolide, a bioactive diterpenoid from Andrographis paniculata, acts as an irreversible NF-κB antagonist. It exhibits anti-inflammatory, anti-platelet, and potential antineoplastic activities, making it a valuable tool for research in oncology, immunology, and cardiovascular disease using both in vitro and in vivo models.

CAS Number

5508-58-7

Product Name Alternative

SARS-CoV, SARS coronavirus, SARSCoV, Andrographis, Andrographolide, Autophagy, NF-kB, NFkB, NFκB, NF-κB, Nuclear factor-κB, Nuclear factor-kappaB, inhibit, Inhibitor, Influenza Virus, InfluenzaVirus

Field of Research

Cell Biology, Immunology & Inflammation

Purity

>98%

Bioactivity

Induces mitochondrial-mediated apoptosis

Form

Powder

Solubility

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 8 mg/ml) .

Smiles

C[C@]12[C@@] ([C@@] (CO) (C) [C@H] (O) CC1) (CCC (=C) [C@H]2C/C=C/3\[C@H] (O) COC3=O) [H]

Molecular Formula

C20H30O6

Molecular Weight

350.5

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Andrographolide

Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties. It has a role as a metabolite, an anti-inflammatory drug, an antineoplastic agent and an anti-HIV agent. It is a primary alcohol, a secondary alcohol, a labdane diterpenoid, a carbobicyclic compound and a gamma-lactone.

CAS Number	5508-58-7
PubChem CID	5318517
IUPAC Name	(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
Molecular Formula	C20H30O5
Molecular Weight	350.4
XLogP	2.2
Topological Polar Surface Area	87
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	25
Formal Charge	0
Complexity	597

SMILES

C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\[C@@H](COC3=O)O)(C)CO)O

InChI

InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChIKey

BOJKULTULYSRAS-OTESTREVSA-N

Chemical Structure

2D Structure

CAS: 5508-58-7

CID: 5318517

Formula: C20H30O5

MW: 350.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	350.4
XLogP3	2.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	350.20932405
Monoisotopic Mass	350.20932405
Topological Polar Surface Area	87 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	597
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR19182080	Andrographiside

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FA17902-01	Andrographolide

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Chemical Information

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