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AMG-337

CAT: 0013-GTR19171334-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171334-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-337 is a potent and selective ATP-competitive inhibitor of the MET kinase, demonstrating an IC50 of less than 5 nM in enzymatic assays. It is a valuable research tool for investigating MET-driven pathologies in both cellular and animal models, with applications in oncology and cancer research.
CAS Number
1173699-31-4
Product Name Alternative
Anticancer, AMG 337, AMG337, AMG-337, cell proliferation, cMet, c-Met, c-Met/HGFR, cMet/HGFR, inhibit, Inhibitor, MKN-45, Met, Met (H1094R), Met (M1250T), Met (V1092I), Met (Y1230H), HGFR, phosphorylation, SNU-5 cells, SNU-620
Field of Research
Cell Biology, Protein Biochemistry, Signal Transduction
Purity
99.26% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.32 mM) ; Ethanol:95 mg/mL (204.98 mM) ; DMSO:50 mg/mL (107.88 mM)
Smiles
COCCOc1cnc2ccn ([C@H] (C) c3nnc4c (F) cc (cn34) -c3cnn (C) c3) c (=O) c2c1
Molecular Formula
C23H22FN7O3
Molecular Weight
463.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Amg-337

AMG-337 is under investigation in clinical trial NCT03147976 (QUILT-3.036: AMG 337 in Subjects With Advanced or Metastatic Solid Tumors).

CAS Number1173699-31-4
PubChem CID44181686
IUPAC Name6-[(1R)-1-[8-fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one
Molecular FormulaC23H22FN7O3
Molecular Weight463.5
XLogP1.5
Topological Polar Surface Area99.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity760
SMILES
C[C@H](C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=C(C4=O)C=C(C=N5)OCCOC
InChI
InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1
InChIKey
DWHXUGDWKAIASB-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of Amg-337
CAS: 1173699-31-4
CID: 44181686
Formula: C23H22FN7O3
MW: 463.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight463.5
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass463.17681575
Monoisotopic Mass463.17681575
Topological Polar Surface Area99.7 Ų
Heavy Atom Count34
Formal Charge0
Complexity760
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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