Tetrandrine

CAT: 0013-GTR19171263-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19171263-01Size:100 mg

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Description

Tetrandrine is a natural bisbenzylisoquinoline alkaloid that acts as a calcium channel blocker, inhibiting both voltage-gated calcium channels and Ca2+-activated potassium channels. It is widely used in pharmacological research, including in vitro ion channel studies and in vivo models for investigating cardiovascular and anti-inflammatory pathways.

CAS Number

518-34-3

Product Name Alternative

Ca2+ channels, Calcium Channel, Ca channels, d-Tetrandrine, CalciumChannel, Inhibitor, Fanchinine, Hanfangchin A, KcsA, inhibit, NSC 77037, NSC77037, NSC-77037, Tetrandrine, Potassium Channel, PotassiumChannel, Sinomenine A

Field of Research

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Purity

98.88% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:0.7 mg/mL (1.12 mM) ; DMSO:12.45 mg/mL (19.99 mM)

Smiles

O (C) C1=C2C=3[C@] (CC=4C=C (C (OC) =CC4) OC=5C=CC (C[C@]6 (C7=CC (O2) =C (OC) C=C7CCN6C) [H]) =CC5) (N (C) CCC3C=C1OC) [H]

Molecular Formula

C38H42N2O6

Molecular Weight

622.75

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Tetrandrine

(+)-Tetrandrine is a bisbenzylisoquinoline alkaloid and a member of isoquinolines.

CAS Number	518-34-3
PubChem CID	73078
IUPAC Name	(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene
Molecular Formula	C38H42N2O6
Molecular Weight	622.7
XLogP	6.4
Topological Polar Surface Area	61.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	46
Formal Charge	0
Complexity	979

SMILES

CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC

InChI

InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1

InChIKey

WVTKBKWTSCPRNU-KYJUHHDHSA-N

Chemical Structure

2D Structure

CAS: 518-34-3

CID: 73078

Formula: C38H42N2O6

MW: 622.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	622.7
XLogP3	6.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	622.30428706
Monoisotopic Mass	622.30428706
Topological Polar Surface Area	61.9 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	979
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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289760-01	Tetrandrine

Tetrandrine

Chemical Information

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