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Negletein

CAT: 0013-GTR19171182-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171182-05Size:25 mg
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Description
Negletein (7-O-Methylbaicalein) is a multi-functional flavonoid with demonstrated bioactivity in research models. It exhibits neuroprotective, anti-inflammatory, and antioxidant properties, activating Nrf2 and inhibiting NFAT. Studies show it induces neurite outgrowth in PC12 cells, protects against hypoxia in vivo, and inhibits amyloid-beta oligomerization in vitro.
CAS Number
29550-13-8
Product Name Alternative
7-O-Methylbaicalein, anti-inflammatory, Baicalein-7-methylether, cell, nerve, Negletein, neurite, neuroprotectant, outgrowth, PC12, ILReceptor, IL-1β, inhibit, IL Receptor, Inhibitor, iNOS, Interleukin, Interleukin Related, growth, factor, TNF-α, TNF Receptor, TNFR, Tumor Necrosis Factor Receptor
Field of Research
Cell Biology, Immunology & Inflammation
Purity
98.00% (May vary between batches)
Solubility
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble; DMSO:50 mg/mL (175.9 mM)
Smiles
COc1cc2oc (cc (=O) c2c (O) c1O) -c1ccccc1
Molecular Formula
C16H12O5
Molecular Weight
284.26
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Negletein

Negletein is an ether and a member of flavonoids.

CAS Number29550-13-8
PubChem CID471719
IUPAC Name5,6-dihydroxy-7-methoxy-2-phenylchromen-4-one
Molecular FormulaC16H12O5
Molecular Weight284.26
XLogP3
Topological Polar Surface Area76
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity426
SMILES
COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)O
InChI
InChI=1S/C16H12O5/c1-20-13-8-12-14(16(19)15(13)18)10(17)7-11(21-12)9-5-3-2-4-6-9/h2-8,18-19H,1H3
InChIKey
ZTHLHHDJRXJGRX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Negletein
CAS: 29550-13-8
CID: 471719
Formula: C16H12O5
MW: 284.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight284.26
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass284.06847348
Monoisotopic Mass284.06847348
Topological Polar Surface Area76 Ų
Heavy Atom Count21
Formal Charge0
Complexity426
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T2S0843-01Negletein

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