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Negletein

CAT: 0804-HY-N4285-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4285-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Negletein (5,6-Dihydroxy-7-methoxyflavone) is a flavone found in Scutellaria. Negletein shows anti-inflammatory activity via inhibiting TNF-α and IL-1β with IC50 values of 16.4 and 6.4 μM, respectively. Negletein can activate Nrf2 and inhibit ROS production. Negletein can enhance the neuroprotective effect of nerve growth factor. Negletein can inhibit amyloid beta-peptide release and accumulation. Negletein can inhibit pathogens biofilms formation. Negletein can be used for the researches of cancer, infection, inflammation and neurological disease, such as colon cancer and Alzheimer's disease[1][2][3][4][5].
CAS Number
29550-13-8
Product Name Alternative
5,6-Dihydroxy-7-methoxyflavone
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β; Interleukin Related; Keap1-Nrf2; Reactive Oxygen Species (ROS) ; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/negletein.html
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=C(O)C(O)=C13
Molecular Formula
C16H12O5
Molecular Weight
284.26
Precautions
H315, H319, H335
References & Citations
[1]Phan CW, et al. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors. 2016 Nov 12;42 (6) :591-599.|[2]Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth. Nat Prod Res. 2013;27 (23) :2227-30.|[3]Banerjee P, et al. Multiple mechanisms of iron-induced amyloid beta-peptide accumulation in SHSY5Y cells: protective action of negletein. Neuromolecular Med. 2014 Dec;16 (4) :787-98.|[4]Havermann S, et al. Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein. Pharm Biol. 2016 Sep;54 (9) :1491-502.|[5]Rajendran N, et al. Antimicrobial flavonoids isolated from Indian medicinal plant Scutellaria oblonga inhibit biofilms formed by common food pathogens. Nat Prod Res. 2016 Sep;30 (17) :2002-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-1

Alternative Products

CatalogName
584843Negletein

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