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Elinzanetant

CAT: 0013-GTR19170796-04Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19170796-04Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Elinzanetant
CAS Number
929046-33-3
Product Name Alternative
BAY 3427080, BAY3427080, BAY-3427080, Neurokininreceptor, Neurokinin Receptor, Neurokinin receptor, NK3, NK1, NK receptor, NT 814, NT814, NT-814, inhibit, Inhibitor, Elinzanetant, Tachykinin receptor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.98 mM) ; DMSO:100 mg/mL (149.56 mM)
Smiles
[H][C@]12COCCN1C[C@@H] (CO) N (C2) c1cc (c (cn1) N (C) C (=O) C (C) (C) c1cc (cc (c1) C (F) (F) F) C (F) (F) F) -c1ccc (F) cc1C
Molecular Formula
C33H35F7N4O3
Molecular Weight
668.64
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Elinzanetant

Elinzanetant is a non-hormonal, selective, dual neurokinin 1 (NK-1) and 3 (NK-3) receptor antagonist. On July 23, 2025, it was approved by Health Canada to treat moderate to severe vasomotor symptoms (VMS) associated with menopause. By blocking receptor signaling on kisspeptin/neurokinin B/dynorphin (KNDy) neurons, which are hyperactivated due to estrogen decline in menopause, elinzanetant modulates neuronal activity involved in thermo-regulation. Later the same year, it was approved in the US for the same indication.

CAS Number929046-33-3
PubChem CID16063568
IUPAC NameN-[6-[(7S,9aS)-7-(hydroxymethyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide
Molecular FormulaC33H35F7N4O3
Molecular Weight668.6
XLogP5.9
Topological Polar Surface Area69.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count13
Rotatable Bond Count6
Heavy Atom Count47
Formal Charge0
Complexity1060
SMILES
CC1=C(C=CC(=C1)F)C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4C[C@H]5COCCN5C[C@H]4CO
InChI
InChI=1S/C33H35F7N4O3/c1-19-9-23(34)5-6-26(19)27-13-29(44-16-25-18-47-8-7-43(25)15-24(44)17-45)41-14-28(27)42(4)30(46)31(2,3)20-10-21(32(35,36)37)12-22(11-20)33(38,39)40/h5-6,9-14,24-25,45H,7-8,15-18H2,1-4H3/t24-,25-/m0/s1
InChIKey
DWRIJNIPBUFCQS-DQEYMECFSA-N
Chemical Structure
2D Structure
2D structure of Elinzanetant
CAS: 929046-33-3
CID: 16063568
Formula: C33H35F7N4O3
MW: 668.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight668.6
XLogP35.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count13
Rotatable Bond Count6
Exact Mass668.25973813
Monoisotopic Mass668.25973813
Topological Polar Surface Area69.1 Ų
Heavy Atom Count47
Formal Charge0
Complexity1060
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-109171-01Elinzanetant
HY-109171SElinzanetant-d3
AR-E09562-01Elinzanetant-d6
HY-109171R-01Elinzanetant (Standard)
CS-O-59054Elinzanetant-d9
CS-O-48370Elinzanetant D3

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