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LP-922056

CAT: 0013-GTR19170705-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170705-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LP-922056 is a potent and selective inhibitor of Notum Pectinacetylesterase, demonstrating EC50 values of 21 nM for human and 55 nM for mouse enzymes. This small molecule is a valuable research tool for investigating Wnt signaling modulation in both cellular and animal models of bone regeneration and metabolic disorders.
CAS Number
1365060-22-5
Product Name Alternative
Thickness, Wnt, Wnt/betacatenin, Wnt/b-catenin, Wnt/β-catenin, βcatenin, betacatenin, beta-catenin, cortical, bone, bcatenin, Inhibitor, femur, lipase, Notum, LP922056, LP-922056, LP 922056, inhibit, orally, Pectinacetylesterase, midshaft
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
99.84% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.3 mM) ; DMSO:120 mg/mL (398.96 mM)
Smiles
OC (=O) CSc1ncnc2c (C3CC3) c (Cl) sc12
Molecular Formula
C11H9ClN2O2S2
Molecular Weight
300.78
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-((6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio)acetic acid
CAS Number1365060-22-5
PubChem CID56932967
IUPAC Name2-(6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
Molecular FormulaC11H9ClN2O2S2
Molecular Weight300.8
XLogP3.6
Topological Polar Surface Area117
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count18
Formal Charge0
Complexity343
SMILES
C1CC1C2=C(SC3=C2N=CN=C3SCC(=O)O)Cl
InChI
InChI=1S/C11H9ClN2O2S2/c12-10-7(5-1-2-5)8-9(18-10)11(14-4-13-8)17-3-6(15)16/h4-5H,1-3H2,(H,15,16)
InChIKey
LJYRIWUQISYYHA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-((6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio)acetic acid
CAS: 1365060-22-5
CID: 56932967
Formula: C11H9ClN2O2S2
MW: 300.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight300.8
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass299.9793976
Monoisotopic Mass299.9793976
Topological Polar Surface Area117 Ų
Heavy Atom Count18
Formal Charge0
Complexity343
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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