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Linaprazan

CAT: 0013-GTR19177554-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177554-06Size:100 mg
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Description
Linaprazan (AZD0865) is a potassium-competitive acid blocker (P-CAB) that reversibly inhibits gastric H+, K+-ATPase with an IC50 of 1.0 μM. This small molecule is a research tool for investigating acid-suppressive therapies in both in vitro biochemical assays and in vivo models of gastric acid-related disorders.
CAS Number
248919-64-4
Product Name Alternative
Inhibitor, Linaprazan, inhibit, K+-competitive binding, AZD0865, AZD-0865, AZD 0865, Proton Pump, Potassium Channel, PotassiumChannel
Field of Research
Pharmacology & Drug Discovery
Purity
99.54% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.73 mM) ; DMSO:3.67 mg/mL (10.01 mM)
Smiles
Cc1nc2c (NCc3c (C) cccc3C) cc (cn2c1C) C (=O) NCCO
Molecular Formula
C21H26N4O2
Molecular Weight
366.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Linaprazan

Linaprazan is a small molecule drug. The usage of the INN stem '-prazan' in the name indicates that Linaprazan is a proton pump inhibitor, not dependent on acid activation. Linaprazan is under investigation in clinical trial NCT00206284 (A Dose-finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients Without Erosive Esophagitis.). Linaprazan has a monoisotopic molecular weight of 366.21 Da.

CAS Number248919-64-4
PubChem CID9951066
IUPAC Name8-[(2,6-dimethylphenyl)methylamino]-N-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
Molecular FormulaC21H26N4O2
Molecular Weight366.5
XLogP3.4
Topological Polar Surface Area78.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity493
SMILES
CC1=C(C(=CC=C1)C)CNC2=CC(=CN3C2=NC(=C3C)C)C(=O)NCCO
InChI
InChI=1S/C21H26N4O2/c1-13-6-5-7-14(2)18(13)11-23-19-10-17(21(27)22-8-9-26)12-25-16(4)15(3)24-20(19)25/h5-7,10,12,23,26H,8-9,11H2,1-4H3,(H,22,27)
InChIKey
GHVIMBCFLRTFHI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Linaprazan
CAS: 248919-64-4
CID: 9951066
Formula: C21H26N4O2
MW: 366.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight366.5
XLogP33.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass366.20557608
Monoisotopic Mass366.20557608
Topological Polar Surface Area78.7 Ų
Heavy Atom Count27
Formal Charge0
Complexity493
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP13535-01Linaprazan
MBS5782324Linaprazan mesylate
A20526-5Linaprazan 5mg
MBS3616756-01Linaprazan glurate
HY-100412RLinaprazan (Standard)
HY-100412ALinaprazan (mesylate)
A20526-100Linaprazan 100mg
A20526-50Linaprazan 50mg
A20526-25Linaprazan 25mg
A20526-10Linaprazan 10mg

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