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Linaprazan (Standard)

CAT: 0804-HY-100412RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100412RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Linaprazan (Standard) is the analytical standard of Linaprazan. This product is intended for research and analytical applications. Linaprazan (AZD0865) can inhibit H+, K+ -ATPase in the stomach through K+ competitive binding, (IC50: 1.0 ± 0.2 μM), it has a strong inhibitory effect on acid. Linaprazan (AZD0865) can be used for research on reflux esophagitis with oral activity[1][2][3].
CAS Number
248919-64-4
Product Name Alternative
AZD0865 (Standard)
UNSPSC
12352005
Target
Proton Pump; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Smiles
O=C(C1=CN2C(C(NCC3=C(C)C=CC=C3C)=C1)=NC(C)=C2C)NCCO
Molecular Formula
C21H26N4O2
Molecular Weight
366.46
References & Citations
[2]Kahrilas PJ et al. A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clin Gastroenterol Hepatol. 2007 Dec;5 (12) :1385-91.|[3]Xinyue Zhang, et al. Absorption, distribution, metabolism and excretion of linaprazan glurate in rats. J Pharm Biomed Anal. 2024 May 15:242:116012.|[1]Gedda K et al. Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+, K+-ATPase. Biochem Pharmacol. 2007 Jan 15;73 (2) :198-205.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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