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Methimazole

CAT: 0013-GTR19177540-04Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19177540-04Size:1 g
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Description
Methimazole (Thiamazole) is a hepatotoxic antithyroid agent used to induce and study hyperthyroidism in experimental models. It is widely applied in both in vitro and in vivo research to investigate thyroid hormone synthesis, drug-induced liver injury, and autoimmune thyroid disease mechanisms.
CAS Number
60-56-0
Product Name Alternative
Cytotoxicity, antithyroid, hepatotoxicity, hepatocytes, Inhibitor, Methimazole, inhibit, Tapazole, THR, Thiamazole, Thyroid hormone receptor, Thyroidhormonereceptor (THR), Thyroidhormonereceptor, Thyroid peripheral conversion, Thyroid hormone receptor (THR)
Field of Research
Metabolism Research
Purity
99.21% (May vary between batches)
Solubility
H2O:21 mg/mL (183.94 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (17.52 mM) ; DMSO:60 mg/mL (525.53 mM) ; Ethanol:22 mg/mL (192.7 mM)
Smiles
CN1C=CN=C1S
Molecular Formula
C4H6N2S
Molecular Weight
114.17
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Methimazole

Methimazole can cause developmental toxicity according to state or federal government labeling requirements.

CAS Number60-56-0
PubChem CID1349907
IUPAC Name3-methyl-1H-imidazole-2-thione
Molecular FormulaC4H6N2S
Molecular Weight114.17
XLogP-0.3
Topological Polar Surface Area47.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count7
Formal Charge0
Complexity119
SMILES
CN1C=CNC1=S
InChI
InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
InChIKey
PMRYVIKBURPHAH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Methimazole
CAS: 60-56-0
CID: 1349907
Formula: C4H6N2S
MW: 114.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight114.17
XLogP3-0.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass114.02516937
Monoisotopic Mass114.02516937
Topological Polar Surface Area47.4 Ų
Heavy Atom Count7
Formal Charge0
Complexity119
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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