Methimazole

• Description:

  Methimazole (Thiamazole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity[1][2][4].

• Product Name Alternative:

  Thiamazole

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H317, H319

• Target:

  Thyroid Hormone Receptor

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Field of Research:

  Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/methimazole.html

• Purity:

  99.97

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL

• Smiles:

  S=C1NC=CN1C

• Molecular Formula:

  C4H6N2S

• Molecular Weight:

  114.17

• Precautions:

  H302, H317, H319

• References & Citations:

  [1]Heidari R, et, al. Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole-Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine. Adv Pharm Bull. 2014;4 (1) :21-8.|[2]Crescioli C, et al. Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. J Endocrinol. 2007 Oct;195 (1) :145-55.|[3]Tatara MR, et al. Effects of long-term oral administration of methimazole on femur and tibia properties in male Wistar rats. Biomed Pharmacother. 2017 Oct;94:124-128.|[4]Reza Heidari, et al. Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes. Drug Chem Toxicol. 2013 Oct;36 (4) :403-11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [60-56-0]