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IWR-1 endo

CAT: 0013-GTR19174800-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174800-01Size:5 mg
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Description
IWR-1-endo is a potent small molecule inhibitor of the Wnt signaling pathway with an EC50 of 0.2 μM, functioning by stabilizing the Axin destruction complex. It is widely used in biochemical and cellular research, including studies of stem cell differentiation and cancer biology, both in vitro and in vivo.
CAS Number
1127442-82-3
Product Name Alternative
Bcatenin, beta-catenin, betacatenin, inhibit, IWR 1, IWR1, IWR-1, IWR-1-endo, Inhibitor, endo-IWR 1, βcatenin, Wnt/β-catenin, Wnt, Wnt/betacatenin, Wnt/b-catenin
Field of Research
Cancer Biology, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Tankyrase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 10 mg/ml)
Smiles
O=C (Nc1cccc2cccnc12) c1ccc (cc1) N1C (=O) C2C3CC (C=C3) C2C1=O
Molecular Formula
C25H19N3O2
Molecular Weight
409.4
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4- (1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl) -N-8-quinolinyl-benzamide

Chemical Information

IWR-1-endo

IWR-1-endo is a dicarboximide having an endo bridged phthalimide structure, substituted at nitrogen by a 4-(quinolin-8-ylcarbamoyl)benzoyl group. It has a role as an axin stabilizer and a Wnt signalling inhibitor. It is a member of benzamides, a member of quinolines, a dicarboximide and a bridged compound.

CAS Number1127442-82-3
PubChem CID44483163
IUPAC Name4-[(1R,2S,6R,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-quinolin-8-ylbenzamide
Molecular FormulaC25H19N3O3
Molecular Weight409.4
XLogP2.9
Topological Polar Surface Area79.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count31
Formal Charge0
Complexity772
SMILES
C1[C@@H]2C=C[C@H]1[C@@H]3[C@H]2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6
InChI
InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+
InChIKey
ZGSXEXBYLJIOGF-ALFLXDJESA-N
Chemical Structure
2D Structure
2D structure of IWR-1-endo
CAS: 1127442-82-3
CID: 44483163
Formula: C25H19N3O3
MW: 409.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight409.4
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass409.14264148
Monoisotopic Mass409.14264148
Topological Polar Surface Area79.4 Ų
Heavy Atom Count31
Formal Charge0
Complexity772
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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