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CC-115

CAT: 0013-GTR19172171-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19172171-03Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CC-115 is a potent dual inhibitor of mTOR and DNA-PK with IC50 values of 21 nM and 13 nM, respectively. It is a valuable research tool for studying DNA damage response and signaling pathways in oncology research, applicable in both cellular and animal models.
CAS Number
1228013-15-7
Product Name Alternative
Inhibit, mTOR, Inhibitor, Mammalian target of Rapamycin, DNA-dependent protein kinase, DNAPK, DNA-PK, CC115, CC-115, CC 115, PI3Kα
Field of Research
Molecular Biology, Signal Transduction
Purity
86.79% (May vary between batches)
Solubility
DMSO:62 mg/mL (184.33 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.95 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CCN1C (=O) CNc2ncc (nc12) -c1ccc (nc1C) -c1ncn[nH]1
Molecular Formula
C16H16N8O
Molecular Weight
336.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cc-115

CC-115 has been used in trials studying the treatment of Prostate Cancer, Neoplasm Metastasis, Ewing's Osteosarcoma, Glioblastoma Multiforme, and Chronic Lymphocytic Leukemia, among others.

CAS Number1228013-15-7
PubChem CID58298318
IUPAC Name5-ethyl-3-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one
Molecular FormulaC16H16N8O
Molecular Weight336.35
XLogP0.7
Topological Polar Surface Area113
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity491
SMILES
CCN1C(=O)CNC2=NC=C(N=C21)C3=C(N=C(C=C3)C4=NC=NN4)C
InChI
InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)
InChIKey
GMYLVKUGJMYTFB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cc-115
CAS: 1228013-15-7
CID: 58298318
Formula: C16H16N8O
MW: 336.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight336.35
XLogP30.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass336.14470716
Monoisotopic Mass336.14470716
Topological Polar Surface Area113 Ų
Heavy Atom Count25
Formal Charge0
Complexity491
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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