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SB 328437

CAT: 0013-GTR19173898-08Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173898-08Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB 328437 is a potent and selective CCR3 antagonist with an IC50 of 4.5 nM. This small molecule is a valuable research tool for studying CCR3-mediated pathways in allergic inflammation and asthma, applicable in both in vitro and in vivo experimental models.
CAS Number
247580-43-4
Product Name Alternative
(S) -methyl 2- (1-naphthamido) -3- (4-nitrophenyl) propanoate, CCR3, ZINC 29222893, ZINC29222893, ZINC-29222893, SB328437, SB-328437, SB 328437
Field of Research
Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery
Purity
99.11% (May vary between batches)
Solubility
DMSO:100 mg/mL (264.28 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (8.72 mM)
Smiles
COC (=O) [C@H] (Cc1ccc (cc1) [N+] ([O-]) =O) NC (=O) c1cccc2ccccc12
Molecular Formula
C21H18N2O5
Molecular Weight
378.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

SB 328437

a CC chemokine receptor-3 antagonist that inhibits binding of eotaxin and monocyte chemotactic protein-4 to eosinophils; structure in first source

CAS Number247580-43-4
PubChem CID10474776
IUPAC Namemethyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate
Molecular FormulaC21H18N2O5
Molecular Weight378.4
XLogP4.2
Topological Polar Surface Area101
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity568
SMILES
COC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32
InChI
InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChIKey
VMFGCGRAIBLAFY-IBGZPJMESA-N
Chemical Structure
2D Structure
2D structure of SB 328437
CAS: 247580-43-4
CID: 10474776
Formula: C21H18N2O5
MW: 378.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.4
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass378.12157168
Monoisotopic Mass378.12157168
Topological Polar Surface Area101 Ų
Heavy Atom Count28
Formal Charge0
Complexity568
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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