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Tafamidis

CAT: 0013-GTR19170541-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170541-01Size:5 mg
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Description
Tafamidis is a kinetic stabilizer of transthyretin (TTR) that inhibits amyloidogenesis by binding with negative cooperativity to stabilize the tetramer. It effectively stabilizes both wild-type and mutant TTR (e.g., V30M, V122I) under physiological and denaturing conditions in vitro and ex vivo. This small molecule is a key research tool for studying TTR amyloidosis mechanisms and therapeutic strategies.
CAS Number
594839-88-0
Product Name Alternative
PF-06291826
Field of Research
Neuroscience
Purity
>98%
Bioactivity
Transthyretin stabilizer
Form
Powder
Solubility
Soluble in DMSO up to 20 mg/ml
Smiles
ClC=1C=C (C=2OC=3C (N2) =CC=C (C (O) =O) C3) C=C (Cl) C1
Molecular Formula
C14H7Cl2NO3
Molecular Weight
308.1
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2- (3,5-Dichlorophenyl) -6-benzoxazolecarboxylic acid

Chemical Information

Tafamidis

Tafamidis is a member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis. It has a role as a central nervous system drug. It is a dichlorobenzene, a monocarboxylic acid and a member of 1,3-benzoxazoles. It is a conjugate acid of a tafamidis(1-).

CAS Number594839-88-0
PubChem CID11001318
IUPAC Name2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
Molecular FormulaC14H7Cl2NO3
Molecular Weight308.1
XLogP4.2
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity371
SMILES
C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
InChI
InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
InChIKey
TXEIIPDJKFWEEC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tafamidis
CAS: 594839-88-0
CID: 11001318
Formula: C14H7Cl2NO3
MW: 308.1
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight308.1
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass306.9802985
Monoisotopic Mass306.9802985
Topological Polar Surface Area63.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity371
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8568-5Tafamidis

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