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9-Methoxycanthin-6-one

CAT: 0013-GTR19170505-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170505-07Size:100 mg
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Description
9-Methoxycanthin-6-one is a bioactive alkaloid demonstrating cytotoxic effects against a range of human cancer cell lines, including KB, LU-1, LNCaP, and HL-60, with IC50 values typically between 1 and 4 μg/mL. It serves as a valuable research tool for investigating anticancer mechanisms in vitro and has been studied in preliminary in vivo models for its antitumor potential.
CAS Number
74991-91-6
Product Name Alternative
Inhibit, fibrous, explants, Inhibitor, cultures, anti-tumour, callus, 9 Methoxycanthin 6 one, 9Methoxycanthin6one, 9-Methoxycanthin-6-one, roots
Field of Research
Cell Biology
Purity
99.61% (May vary between batches)
Solubility
DMSO:4 mg/mL (15.98 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4 mM)
Smiles
COc1ccc2c3ccnc4ccc (=O) n (c2c1) c34
Molecular Formula
C15H10N2O2
Molecular Weight
250.25
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

9-Methoxy-6H-indolo(3,2,1-de)(1,5)naphthyridin-6-one

9-methoxycanthin-6-one is an indole alkaloid that is the 9-methoxy derivative of canthin-6-one. Isolated from Eurycoma longifolia and Simaba multiflora, it exhibits cytotoxic activity towards human cancer cell lines. It has a role as a metabolite, an antineoplastic agent and an antiplasmodial drug. It is an aromatic ether, an organic heterotetracyclic compound and an indole alkaloid. It is functionally related to a canthin-6-one.

CAS Number74991-91-6
PubChem CID9881423
IUPAC Name13-methoxy-1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),6,8,10,12,14-heptaen-2-one
Molecular FormulaC15H10N2O2
Molecular Weight250.25
XLogP2.4
Topological Polar Surface Area44.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity422
SMILES
COC1=CC2=C(C=C1)C3=C4N2C(=O)C=CC4=NC=C3
InChI
InChI=1S/C15H10N2O2/c1-19-9-2-3-10-11-6-7-16-12-4-5-14(18)17(15(11)12)13(10)8-9/h2-8H,1H3
InChIKey
OWCRARVHWCCRAG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 9-Methoxy-6H-indolo(3,2,1-de)(1,5)naphthyridin-6-one
CAS: 74991-91-6
CID: 9881423
Formula: C15H10N2O2
MW: 250.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight250.25
XLogP32.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass250.074227566
Monoisotopic Mass250.074227566
Topological Polar Surface Area44.1 Ų
Heavy Atom Count19
Formal Charge0
Complexity422
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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