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HG-14-10-04

CAT: 0013-GTR19170045-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170045-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HG-14-10-04 is a highly selective small molecule inhibitor targeting the anaplastic lymphoma kinase (ALK) . It is a valuable research tool for investigating ALK-driven pathologies, such as certain cancers, in both cellular (in vitro) and animal (in vivo) experimental models.
CAS Number
1356962-34-9
Product Name Alternative
CD246, Cluster of differentiation 246, ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase (ALK), Anaplastic lymphoma kinase, anticancer, inhibit, Inhibitor, HG 14 10 04, HG141004, HG-14-10-04, HER1, Epidermal growth factor receptor, ErbB-1, EGFR
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.36% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.88 mM) ; DMSO:5.33 mg/mL (10.02 mM)
Smiles
COc1cc (ccc1Nc1ncc (Cl) c (n1) -c1c[nH]c2ccccc12) N1CCC (CC1) N1CCN (C) CC1
Molecular Formula
C29H34ClN7O
Molecular Weight
532.08
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine

5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2-pyrimidinamine is a member of piperidines.

CAS Number1356962-34-9
PubChem CID56655374
IUPAC Name5-chloro-4-(1H-indol-3-yl)-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine
Molecular FormulaC29H34ClN7O
Molecular Weight532.1
XLogP5
Topological Polar Surface Area72.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count38
Formal Charge0
Complexity746
SMILES
CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)C5=CNC6=CC=CC=C65)Cl)OC
InChI
InChI=1S/C29H34ClN7O/c1-35-13-15-37(16-14-35)20-9-11-36(12-10-20)21-7-8-26(27(17-21)38-2)33-29-32-19-24(30)28(34-29)23-18-31-25-6-4-3-5-22(23)25/h3-8,17-20,31H,9-16H2,1-2H3,(H,32,33,34)
InChIKey
HRYNCLKDKCPYBF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine
CAS: 1356962-34-9
CID: 56655374
Formula: C29H34ClN7O
MW: 532.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight532.1
XLogP35
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass531.2513364
Monoisotopic Mass531.2513364
Topological Polar Surface Area72.6 Ų
Heavy Atom Count38
Formal Charge0
Complexity746
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA6348-100HG-14-10-04
A16267-5HG-14-10-04 5mg
A16267-200HG-14-10-04 200mg
A16267-25HG-14-10-04 25mg
A16267-100HG-14-10-04 100mg
A16267-50HG-14-10-04 50mg
A16267-10HG-14-10-04 10mg
A16267-1HG-14-10-04 1mg

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