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L48H37

CAT: 0013-GTR19169999-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169999-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L48H37 is a chemically stable curcumin analog that acts as a specific myeloid differentiation protein 2 (MD2) inhibitor. It blocks LPS-TLR4/MD2 signaling and is applied in research models of sepsis and acute lung injury, both in vitro and in vivo.
CAS Number
343307-76-6
Product Name Alternative
Asthma, Curcumin, lung injury, LPS-TLR4/MD2, Inflammation, IL-6, inhibit, L48H37, L-48H37, Inhibitor, TLR4/MD2, Sepsis, TNF-α, Toll-like Receptor (TLR)
Field of Research
Immunology & Inflammation
Purity
98.42% (May vary between batches)
Solubility
DMSO:45 mg/mL (93.06 mM)
Smiles
CCN1C\C (=C/c2cc (OC) c (OC) c (OC) c2) C (=O) \C (C1) =C\c1cc (OC) c (OC) c (OC) c1
Molecular Formula
C27H33NO7
Molecular Weight
483.55
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(3E,5E)-1-ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one
CAS Number343307-76-6
PubChem CID6523614
IUPAC Name(3E,5E)-1-ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one
Molecular FormulaC27H33NO7
Molecular Weight483.6
XLogP3.8
Topological Polar Surface Area75.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Heavy Atom Count35
Formal Charge0
Complexity668
SMILES
CCN1C/C(=C\C2=CC(=C(C(=C2)OC)OC)OC)/C(=O)/C(=C/C3=CC(=C(C(=C3)OC)OC)OC)/C1
InChI
InChI=1S/C27H33NO7/c1-8-28-15-19(9-17-11-21(30-2)26(34-6)22(12-17)31-3)25(29)20(16-28)10-18-13-23(32-4)27(35-7)24(14-18)33-5/h9-14H,8,15-16H2,1-7H3/b19-9+,20-10+
InChIKey
IOFNKUXFKVPLPF-LQGKIZFRSA-N
Chemical Structure
2D Structure
2D structure of (3E,5E)-1-ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one
CAS: 343307-76-6
CID: 6523614
Formula: C27H33NO7
MW: 483.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight483.6
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass483.22570239
Monoisotopic Mass483.22570239
Topological Polar Surface Area75.7 Ų
Heavy Atom Count35
Formal Charge0
Complexity668
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA6301-100L48H37

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