L48H37

CAT: 0804-HY-126154-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-126154-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

L48H37 is an analog of Curcumin with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment[1].

CAS Number

343307-76-6

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/l48h37.html

Purity

97.13

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1/C(CN(C/C1=C\C2=CC(OC)=C(C(OC)=C2)OC)CC)=C/C3=CC(OC)=C(C(OC)=C3)OC

Molecular Formula

C27H33NO7

Molecular Weight

483.55

Precautions

H315, H319, H320

References & Citations

[1]Yi Wang, et al. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353 (3) :539-50|[2]Chen Feng, et al. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56 (7) :1765-1777.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR4

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