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CAY10602

CAT: 0013-GTR19169962-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169962-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAY10602 is a potent and selective SIRT1 activator identified via high-throughput screening. It dose-dependently inhibits NF-κB signaling and TNF-α production, as demonstrated in LPS-stimulated THP-1 cell assays with ~75% inhibition at 60 μM. This compound is a valuable research tool for studying SIRT1's role in inflammation, aging, and metabolic pathways in vitro.
CAS Number
374922-43-7
Product Name Alternative
Inhibit, Inhibitor, CAY10602, CAY-10602, CAY 10602, Sirtuin, SIRT1
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
98.87% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.78 mM) ; DMSO:41.8 mg/mL (99.89 mM)
Smiles
Nc1c (c2nc3ccccc3nc2n1-c1ccc (F) cc1) S (=O) (=O) c1ccccc1
Molecular Formula
C22H15FN4O2S
Molecular Weight
418.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
CAS Number374922-43-7
PubChem CID1915791
IUPAC Name3-(benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine
Molecular FormulaC22H15FN4O2S
Molecular Weight418.4
XLogP4.5
Topological Polar Surface Area99.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity702
SMILES
C1=CC=C(C=C1)S(=O)(=O)C2=C(N(C3=NC4=CC=CC=C4N=C23)C5=CC=C(C=C5)F)N
InChI
InChI=1S/C22H15FN4O2S/c23-14-10-12-15(13-11-14)27-21(24)20(30(28,29)16-6-2-1-3-7-16)19-22(27)26-18-9-5-4-8-17(18)25-19/h1-13H,24H2
InChIKey
CSFVFDHRYKBBPD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
CAS: 374922-43-7
CID: 1915791
Formula: C22H15FN4O2S
MW: 418.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.4
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass418.08997507
Monoisotopic Mass418.08997507
Topological Polar Surface Area99.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity702
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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530654CAY10602
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A19395-100CAY10602 100mg
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A19395-5CAY10602 5mg
A19395-10mM-DCAY10602 10mM * 1mL in DMSO

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