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Butein

CAT: 0013-GTR19169940-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169940-01Size:1 mg
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Description
Butein is a multi-target small molecule that acts as a cAMP-specific PDE inhibitor, a protein tyrosine kinase inhibitor, and a SIRT1 activator. Research indicates it can sensitize HeLa cells to Cisplatin-induced cytotoxicity by modulating FoxO3a through the AKT and ERK/p38 MAPK signaling pathways, highlighting its utility in cancer research.
CAS Number
487-52-5
Product Name Alternative
Cell, Apoptosis, Autophagy, Butein, AKT, 2',3,4,4'-tetrahydroxy Chalcone, EGFR, Epidermal growth factor receptor, ErbB-1, ERK, FoxO3a, HER1, HepG2, HeLa, MAPK, PDE4, p60c-src, inhibit, Inhibitor, Phosphodiesterase (PDE), phosphodiesterase, PKB, SIRT1, p38
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction
Purity
98.76% (May vary between batches)
Solubility
10% DMSO+90% Saline:2.5 mg/mL (9.18 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:51 mg/mL (187.33 mM) ; DMSO:237.5 mg/mL (872.36 mM)
Smiles
Oc1ccc (C (=O) \C=C\c2ccc (O) c (O) c2) c (O) c1
Molecular Formula
C15H12O5
Molecular Weight
272.25
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Butein

Butein is a chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'. It has a role as a radiosensitizing agent, a geroprotector, an antioxidant, a hypoglycemic agent, an antineoplastic agent, a tyrosine kinase inhibitor, an EC 1.1.1.21 (aldehyde reductase) inhibitor and a plant metabolite. It is a member of chalcones and a polyphenol.

CAS Number487-52-5
PubChem CID5281222
IUPAC Name(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
Molecular FormulaC15H12O5
Molecular Weight272.25
XLogP2.8
Topological Polar Surface Area98
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity367
SMILES
C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O)O
InChI
InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
InChIKey
AYMYWHCQALZEGT-ORCRQEGFSA-N
Chemical Structure
2D Structure
2D structure of Butein
CAS: 487-52-5
CID: 5281222
Formula: C15H12O5
MW: 272.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight272.25
XLogP32.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass272.06847348
Monoisotopic Mass272.06847348
Topological Polar Surface Area98 Ų
Heavy Atom Count20
Formal Charge0
Complexity367
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
TB01739Butein

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