Products for Research Use Only
RegisterLogin

CH7057288

CAT: 0013-GTR19169565-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19169565-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CH7057288 is a potent and selective pan-TRK inhibitor, demonstrating low nanomolar IC50 values against TRKA (1.1 nM), TRKB (7.8 nM), and TRKC (5.1 nM) . It is a valuable research tool for investigating TRK kinase biology in cellular assays and has shown utility in preclinical models of TRK-driven cancers.
CAS Number
2095616-82-1
Product Name Alternative
CH7057288, CH-7057288, CH 7057288, inhibit, Inhibitor, Tropomyosin related kinase receptor, Trkreceptor, Trk Receptor, Trk receptor, Trk
Field of Research
Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:34 mg/mL (59.68 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.51 mM)
Smiles
Cc1cc (cc (n1) C#Cc1ccc2c3c (oc2c1) C (C) (C) c1cc (NS (C) (=O) =O) ccc1C3=O) C (=O) NC (C) (C) C
Molecular Formula
C32H31N3O5S
Molecular Weight
569.67
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(tert-Butyl)-2-((6,6-dimethyl-8-(methylsulfonamido)-11-oxo-6,11-dihydronaphtho[2,3-b]benzofuran-3-yl)ethynyl)-6-methylisonicotinamide
CAS Number2095616-82-1
PubChem CID131839646
IUPAC NameN-tert-butyl-2-[2-[8-(methanesulfonamido)-6,6-dimethyl-11-oxonaphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methylpyridine-4-carboxamide
Molecular FormulaC32H31N3O5S
Molecular Weight569.7
XLogP5.3
Topological Polar Surface Area127
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count41
Formal Charge0
Complexity1210
SMILES
CC1=CC(=CC(=N1)C#CC2=CC3=C(C=C2)C4=C(O3)C(C5=C(C4=O)C=CC(=C5)NS(=O)(=O)C)(C)C)C(=O)NC(C)(C)C
InChI
InChI=1S/C32H31N3O5S/c1-18-14-20(30(37)34-31(2,3)4)16-21(33-18)10-8-19-9-12-24-26(15-19)40-29-27(24)28(36)23-13-11-22(35-41(7,38)39)17-25(23)32(29,5)6/h9,11-17,35H,1-7H3,(H,34,37)
InChIKey
DCGOHGQJHJXBGW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(tert-Butyl)-2-((6,6-dimethyl-8-(methylsulfonamido)-11-oxo-6,11-dihydronaphtho[2,3-b]benzofuran-3-yl)ethynyl)-6-methylisonicotinamide
CAS: 2095616-82-1
CID: 131839646
Formula: C32H31N3O5S
MW: 569.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight569.7
XLogP35.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass569.19844227
Monoisotopic Mass569.19844227
Topological Polar Surface Area127 Ų
Heavy Atom Count41
Formal Charge0
Complexity1210
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8577-50CH7057288
A19241-50CH7057288 50mg
A19241-100CH7057288 100mg
A19241-25CH7057288 25mg
A19241-5CH7057288 5mg
A19241-10CH7057288 10mg
A19241-1CH7057288 1mg
A19241-10mM-DCH7057288 10mM * 1mL in DMSO

Popular Products