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INF7

CAT: 0804-HY-P10152-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10152-02Size:5 mg
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Description
INF7 is a derivative of the N-terminal domain of the HA2 protein and is sensitive to pH. INF7 disrupts the stability of endosomal membranes through a mechanism independent of membrane fusion. INF7 can be used to enhance the endosome escape of complex or liposome-encapsulated proteins. Co-encapsulation of INF7 and molecular imaging probes in liposomes can enhance intracellular signaling and probe retention[1][2].
CAS Number
185462-59-3
UNSPSC
12352209
Target
Biochemical Assay Reagents
Type
Peptides
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/inf7.html
Purity
96.25
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCSC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC7=CC=C(C=C7)O)C(NCC(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C124H169N27O37S2
Molecular Weight
2693.96
References & Citations
[1]Ayman El-Sayed, et al. Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape. J Control Release. 2009 Sep 1;138 (2) :160-7. |[2]Burks SR, et al. Co-encapsulating the fusogenic peptide INF7 and molecular imaging probes in liposomes increases intracellular signal and probe retention. PLoS One. 2015 Mar 27;10 (3) :e0120982.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Gly-Leu-Phe-Glu-Ala-Ile-Glu-Gly-Phe-Ile-Glu-Asn-Gly-Trp-Glu-Gly-Met-Ile-Asp-Gly-Trp-Tyr-Gly-Cys-OH
CAS Number185462-59-3
PubChem CID172899169
IUPAC Name(4S)-4-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-3-carboxy-1-[[2-[[(2S)-1-[[(2S)-1-[[2-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid
Molecular FormulaC124H169N27O37S2
Molecular Weight2694.0
XLogP-2
Topological Polar Surface Area1040
Hydrogen Bond Donor Count35
Hydrogen Bond Acceptor Count40
Rotatable Bond Count85
Heavy Atom Count190
Formal Charge0
Complexity6110
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CC(C)C)NC(=O)CN
InChI
InChI=1S/C124H169N27O37S2/c1-11-64(6)104(149-107(170)67(9)134-113(176)80(38-42-101(164)165)142-117(180)86(48-69-26-18-15-19-27-69)146-116(179)83(46-63(4)5)136-93(154)54-125)121(184)143-79(37-41-100(162)163)109(172)130-58-95(156)137-85(47-68-24-16-14-17-25-68)120(183)151-105(65(7)12-2)122(185)144-81(39-43-102(166)167)114(177)147-89(52-92(126)153)111(174)132-59-96(157)138-87(50-71-55-127-76-30-22-20-28-74(71)76)118(181)141-78(36-40-99(160)161)108(171)129-57-94(155)135-82(44-45-190-10)115(178)150-106(66(8)13-3)123(186)148-90(53-103(168)169)112(175)133-60-97(158)139-88(51-72-56-128-77-31-23-21-29-75(72)77)119(182)145-84(49-70-32-34-73(152)35-33-70)110(173)131-61-98(159)140-91(62-189)124(187)188/h14-35,55-56,63-67,78-91,104-106,127-128,152,189H,11-13,36-54,57-62,125H2,1-10H3,(H2,126,153)(H,129,171)(H,130,172)(H,131,173)(H,132,174)(H,133,175)(H,134,176)(H,135,155)(H,136,154)(H,137,156)(H,138,157)(H,139,158)(H,140,159)(H,141,181)(H,142,180)(H,143,184)(H,144,185)(H,145,182)(H,146,179)(H,147,177)(H,148,186)(H,149,170)(H,150,178)(H,151,183)(H,160,161)(H,162,163)(H,164,165)(H,166,167)(H,168,169)(H,187,188)/t64-,65-,66-,67-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,104-,105-,106-/m0/s1
InChIKey
LZTHPTLSXVZKSR-VHPRXMNCSA-N
Chemical Structure
2D Structure
2D structure of H-Gly-Leu-Phe-Glu-Ala-Ile-Glu-Gly-Phe-Ile-Glu-Asn-Gly-Trp-Glu-Gly-Met-Ile-Asp-Gly-Trp-Tyr-Gly-Cys-OH
CAS: 185462-59-3
CID: 172899169
Formula: C124H169N27O37S2
MW: 2694.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight2694.0
XLogP3-2
Hydrogen Bond Donor Count35
Hydrogen Bond Acceptor Count40
Rotatable Bond Count85
Exact Mass2693.1647666
Monoisotopic Mass2692.1614118
Topological Polar Surface Area1040 Ų
Heavy Atom Count190
Formal Charge0
Complexity6110
Isotope Atom Count0
Defined Atom Stereocenter Count21
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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