Products for Research Use Only
RegisterLogin

CFT7455

CAT: 0013-GTR19168786-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19168786-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CFT7455 (Cemsidomide) is a potent, orally bioavailable cereblon E3 ligase binder (Kd = 0.9 nM) that induces the degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) . It is a research compound for studying hematological cancers, with demonstrated activity in both cellular assays and in vivo models.
CAS Number
2504235-67-8
Product Name Alternative
Anti-cancer agent, CFT7455, CFT-7455, CFT 7455, cereblon, cereblon (CRBN) E3 ligase, Cemsidomide, E3 ligase-recruiting Moiety, inhibit, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, orally active, Inhibitor, IKZF1, IKZF3 degrader
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
97.93% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.26 mM) ; DMSO:20 mg/mL (42.6 mM)
Smiles
[H][C@@]1 (CCC (=O) NC1=O) N1C (=O) c2cccc3c (Cc4ccc (CN5CCOCC5) cc4) ccc1c23
Molecular Formula
C28H27N3O4
Molecular Weight
469.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cemsidomide

Cemsidomide is an orally bioavailable modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. Upon oral administration, cemsidomide specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. This also leads to downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the CRL4-CRBN E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.

CAS Number2504235-67-8
PubChem CID155207651
IUPAC Name(3S)-3-[6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione
Molecular FormulaC28H27N3O4
Molecular Weight469.5
XLogP2.9
Topological Polar Surface Area79
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge0
Complexity819
SMILES
C1CC(=O)NC(=O)[C@H]1N2C3=C4C(=C(C=C3)CC5=CC=C(C=C5)CN6CCOCC6)C=CC=C4C2=O
InChI
InChI=1S/C28H27N3O4/c32-25-11-10-24(27(33)29-25)31-23-9-8-20(21-2-1-3-22(26(21)23)28(31)34)16-18-4-6-19(7-5-18)17-30-12-14-35-15-13-30/h1-9,24H,10-17H2,(H,29,32,33)/t24-/m0/s1
InChIKey
MUKCJOOKCZSQNW-DEOSSOPVSA-N
Chemical Structure
2D Structure
2D structure of Cemsidomide
CAS: 2504235-67-8
CID: 155207651
Formula: C28H27N3O4
MW: 469.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight469.5
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass469.20015635
Monoisotopic Mass469.20015635
Topological Polar Surface Area79 Ų
Heavy Atom Count35
Formal Charge0
Complexity819
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
E1184-25mgCFT7455
T63024-01(Rac) -CFT7455
JH914957(S) -CFT7455
MBS5805699(Rac)-CFT7455

Popular Products