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Cabozantinib hydrochloride

CAT: 0013-GTR19168589-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168589-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cabozantinib hydrochloride (XL184) is a multi-targeted tyrosine kinase inhibitor with potent activity against key receptors including VEGFR2, c-Met, Kit, Axl, and Flt4. It is widely used in preclinical research to investigate tumor angiogenesis, metastasis, and proliferation in both cellular assays and animal models of various cancers.
CAS Number
1817759-42-4
Product Name Alternative
Cluster of differentiation antigen 135, CD135, CD117, c-Kit, cKit, c-Met/HGFR, cMet/HGFR, cMet, c-Met, antiangiogenic, Apoptosis, angiogenesis, B16F10 cells, Axl, Cabozantinib, Cabozantinib hydrochloride, Cabozantinib Hydrochloride, Cabozantinib hydrochloride (849217-68-1 (free base) ), BMS 907351, BMS907351, BMS-907351, A431, Inhibitor, inhibit, Mer, HGFR, Fms like tyrosine kinase 3, HT1080, FLT4, FLT3, Tyro3, VEGFR2/KDR, VEGFR, Vascular endothelial growth factor receptor, RORγ, RORα, TAMReceptor, TAM Receptor, SCFR, XL 184, XL184, XL-184
Field of Research
Cardiovascular Research, Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
97.09% (May vary between batches)
Solubility
DMSO:5.38 mg/mL (10 mM)
Smiles
Cl.COc1cc2nccc (Oc3ccc (NC (=O) C4 (CC4) C (=O) Nc4ccc (F) cc4) cc3) c2cc1OC
Molecular Formula
C28H25ClFN3O5
Molecular Weight
537.96
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N'1-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride
CAS Number1817759-42-4
PubChem CID122573030
IUPAC Name1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;hydrochloride
Molecular FormulaC28H25ClFN3O5
Molecular Weight538.0
Topological Polar Surface Area98.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count38
Formal Charge0
Complexity795
SMILES
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.Cl
InChI
InChI=1S/C28H24FN3O5.ClH/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);1H
InChIKey
LCNVAOXPKXBXEH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N'1-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide hydrochloride
CAS: 1817759-42-4
CID: 122573030
Formula: C28H25ClFN3O5
MW: 538.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight538.0
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass537.1466768
Monoisotopic Mass537.1466768
Topological Polar Surface Area98.8 Ų
Heavy Atom Count38
Formal Charge0
Complexity795
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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