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AUT1

CAT: 0013-GTR19168571-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168571-01Size:1 mg
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Description
AUT1 is a novel and specific positive modulator of Kv3.1b and Kv3.2a potassium channels, exhibiting EC50 values of 4.7 μM and 4.9 μM, respectively. This small molecule is a valuable research tool for investigating Kv3 channel function in neuronal excitability, fast-spiking neurons, and potential therapeutic applications for neurological disorders in both in vitro and in vivo models.
CAS Number
1311136-84-1
Product Name Alternative
AUT 1, AUT1, AUT-1, dysfunction, corticolimbic circuits, human recombinant, Inhibitor, KcsA, Kv3.1b, Kv3.1b channels, Kv3.2a, Kv3.2a channels, inhibit, schizophrenia, Potassium Channel, PotassiumChannel, recombinant human Kv3 channels
Field of Research
Pharmacology & Drug Discovery
Purity
99.43% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.65 mM) ; DMSO:250 mg/mL (732.36 mM)
Smiles
CC[C@H]1NC (=O) N (C1=O) c1ccc (Oc2ccc (C) c (OC) c2) nc1
Molecular Formula
C18H19N3O4
Molecular Weight
341.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
CAS Number1311136-84-1
PubChem CID53230344
IUPAC Name(5R)-5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]imidazolidine-2,4-dione
Molecular FormulaC18H19N3O4
Molecular Weight341.4
XLogP2.8
Topological Polar Surface Area80.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity501
SMILES
CC[C@@H]1C(=O)N(C(=O)N1)C2=CN=C(C=C2)OC3=CC(=C(C=C3)C)OC
InChI
InChI=1S/C18H19N3O4/c1-4-14-17(22)21(18(23)20-14)12-6-8-16(19-10-12)25-13-7-5-11(2)15(9-13)24-3/h5-10,14H,4H2,1-3H3,(H,20,23)/t14-/m1/s1
InChIKey
AMAOXEGBJHLCSF-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
CAS: 1311136-84-1
CID: 53230344
Formula: C18H19N3O4
MW: 341.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight341.4
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass341.13755610
Monoisotopic Mass341.13755610
Topological Polar Surface Area80.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity501
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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