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Danirixin

CAT: 0013-GTR19168561-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19168561-02Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Danirixin (GSK1325756) is a selective and potent CXCR2 antagonist, inhibiting IL-8 binding with an IC50 of 12.5 nM. This small molecule is a valuable research tool for investigating the role of CXCR2 in neutrophil-mediated inflammation in both in vitro and in vivo models.
CAS Number
954126-98-8
Product Name Alternative
Danirixin, CXC chemokine receptors, CXCR, CXCR2, Inhibitor, GSK 1325756, GSK1325756, GSK-1325756, inhibit
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:60 mg/mL (135.78 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (11.31 mM)
Smiles
Cc1c (F) cccc1NC (=O) Nc1ccc (Cl) c (c1O) S (=O) (=O) [C@H]1CCCNC1
Molecular Formula
C19H21ClFN3O4S
Molecular Weight
441.9
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Danirixin

Danirixin has been used in trials studying the treatment and basic science of Virus Diseases, Nutritional Status, Pulmonary Disease, Chronic Obstructive, and Infections, Respiratory Syncytial Virus.

CAS Number954126-98-8
PubChem CID24780598
IUPAC Name1-[4-chloro-2-hydroxy-3-[(3S)-piperidin-3-yl]sulfonylphenyl]-3-(3-fluoro-2-methylphenyl)urea
Molecular FormulaC19H21ClFN3O4S
Molecular Weight441.9
XLogP3.1
Topological Polar Surface Area116
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity677
SMILES
CC1=C(C=CC=C1F)NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)[C@H]3CCCNC3)O
InChI
InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27,28)12-4-3-9-22-10-12/h2,5-8,12,22,25H,3-4,9-10H2,1H3,(H2,23,24,26)/t12-/m0/s1
InChIKey
NGYNBSHYFOFVLS-LBPRGKRZSA-N
Chemical Structure
2D Structure
2D structure of Danirixin
CAS: 954126-98-8
CID: 24780598
Formula: C19H21ClFN3O4S
MW: 441.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight441.9
XLogP33.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass441.0925332
Monoisotopic Mass441.0925332
Topological Polar Surface Area116 Ų
Heavy Atom Count29
Formal Charge0
Complexity677
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M16816-01Danirixin
C12062-10mM/1mLDanirixin (GSK1325756)
MBS131047-01Danirixin ?GSK1325756?
A20792-50Danirixin 50mg
A20792-25Danirixin 25mg
A20792-1Danirixin 1mg
A20792-100Danirixin 100mg
A20792-10Danirixin 10mg
A20792-5Danirixin 5mg
A20792-10mM-DDanirixin 10mM * 1mL in DMSO

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