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Rolipram

CAT: 0013-GTR19168215-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168215-01Size:10 mg
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Description
Rolipram (SB 95952) is a selective PDE4 inhibitor used in neuroscience and psychiatric research. It has demonstrated antidepressant-like effects in animal models and is utilized in vitro to study cAMP signaling pathways and neuroinflammation.
CAS Number
61413-54-5
Product Name Alternative
ZK 62711
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
Phosphodiesterase PDE4 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml) .
Smiles
O (C1=C (OC) C=CC (=C1) C2CNC (=O) C2) C3CCCC3
Molecular Formula
C16H21NO3
Molecular Weight
275.4
Storage Conditions
RT
Notes
For research use only.
Other Product Names
4-[3- (Cyclopentyloxy) -4-methoxyphenyl]-2-pyrrolidinone (racemic)

Chemical Information

Rolipram

Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

CAS Number61413-54-5
PubChem CID5092
IUPAC Name4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Molecular FormulaC16H21NO3
Molecular Weight275.34
XLogP2.2
Topological Polar Surface Area47.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity341
SMILES
COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3
InChI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
InChIKey
HJORMJIFDVBMOB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Rolipram
CAS: 61413-54-5
CID: 5092
Formula: C16H21NO3
MW: 275.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight275.34
XLogP32.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass275.15214353
Monoisotopic Mass275.15214353
Topological Polar Surface Area47.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity341
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A4328-50Rolipram
TRC-R640040-10MG(±)-Rolipram

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