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Niraparib tosylate

CAT: 0013-GTR19167982-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167982-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Niraparib tosylate is a potent and selective inhibitor of PARP1 and PARP2 enzymes, exhibiting IC50 values of 3.8 nM and 2.1 nM, respectively. It is widely used in cancer research, particularly for studying synthetic lethality in BRCA-deficient models, and has demonstrated efficacy in both in vitro cellular assays and in vivo tumor xenograft studies.
CAS Number
1038915-73-9
Product Name Alternative
Damage, DNA, breast, Apoptosis, anti-tumor, bioavailable, cancer, Inhibitor, inhibit, lung, poly ADP ribose polymerase, ovarian, Niraparib tosylate, Niraparib Tosylate, Niraparib, Niraparib (MK-4827) tosylate, Niraparib (MK-4827) Tosylate, orally, PARP, PARP1, PARP2, MK 4827, MK 4827 tosylate, MK 4827 Tosylate, MK4827, MK-4827, MK-4827 (tosylate), MK4827 Tosylate, MK-4827 Tosylate
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.19% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:91 mg/mL (184.74 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1ccc (cc1) S (O) (=O) =O.NC (=O) c1cccc2cn (nc12) -c1ccc (cc1) [C@@H]1CCCNC1
Molecular Formula
C19H20N4O·C7H8O3S
Molecular Weight
492.59
Storage Conditions
-20°C
Notes
For research use only.

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