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Niraparib

CAT: 0013-GTR19172593-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172593-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Niraparib (MK-4827) is a potent and selective PARP1/2 inhibitor (IC50=3.8/2.1 nM) that impedes DNA repair, leading to apoptosis. It is widely used in oncology research, demonstrating antitumor efficacy in both cellular assays and in vivo models of BRCA-mutated and homologous recombination-deficient cancers.
CAS Number
1038915-60-4
Product Name Alternative
Breast, damage, DNA, bioavailable, cancer, Apoptosis, anti-tumor, Inhibitor, MK-4827, MK4827, MK 4827, PARP2, PARP3, PARP1, PARP, ovarian, poly ADP ribose polymerase, Niraparib, orally, inhibit, lung, TANK-1, V-PARP
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:65.63 mg/mL (204.84 mM) ; Ethanol:60 mg/mL (187.27 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:6 mg/mL (18.73 mM)
Smiles
C (N) (=O) C=1C=2C (=CN (N2) C3=CC=C (C=C3) [C@@H]4CCCNC4) C=CC1
Molecular Formula
C19H20N4O
Molecular Weight
320.39
Storage Conditions
-20°C
Notes
For research use only.

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sc-507492Niraparib
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HY-W759435Niraparib-d5
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HY-10619R-01Niraparib (Standard)

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