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Pluripotin

CAT: 0013-GTR19167928-05Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167928-05Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pluripotin (SC1) is a dual inhibitor of ERK1 (MAPK3) and RasGAP that promotes embryonic stem cell (ESC) self-renewal. It is widely used in stem cell research to maintain pluripotency in vitro and has been applied in studies investigating signaling pathways crucial for development and regeneration.
CAS Number
839707-37-8
Product Name Alternative
Inhibitor, inhibit, Pluripotin, ERK, ERK1, Extracellular signal regulated kinases, SC1, SC-1, SC 1, S6Kinase, S6 Kinase, S6K, Ribosomal S6 Kinase (RSK), RasGAP
Field of Research
Signal Transduction
Purity
98.77% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.63 mM) ; DMSO:13.8 mg/mL (25.07 mM)
Smiles
CN1C (=O) N (Cc2cnc (Nc3cc (C) nn3C) nc12) c1cc (NC (=O) c2cccc (c2) C (F) (F) F) ccc1C
Molecular Formula
C27H25F3N8O2
Molecular Weight
550.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pluripotin

Pluripotin is a member of the class of pyrimidopyrimidines that is 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one substituted by methyl, 2-methyl-5-[3-(trifluoromethyl)benzamido]phenyl, and (1,3-dimethyl-1H-pyrazol-5-yl)amino group at positions 1, 3, and 7, respectively. It is a dual inhibitor of ERK1 and RasGAP. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a secondary carboxamide, a member of benzamides, a member of pyrazoles, a member of toluenes, a pyrimidopyrimidine and a member of (trifluoromethyl)benzenes.

CAS Number839707-37-8
PubChem CID12003241
IUPAC NameN-[3-[7-[(2,5-dimethylpyrazol-3-yl)amino]-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Molecular FormulaC27H25F3N8O2
Molecular Weight550.5
XLogP4
Topological Polar Surface Area108
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count40
Formal Charge0
Complexity925
SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CC(=NN5C)C
InChI
InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)
InChIKey
NBZFRTJWEIHFPF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pluripotin
CAS: 839707-37-8
CID: 12003241
Formula: C27H25F3N8O2
MW: 550.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight550.5
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass550.20525656
Monoisotopic Mass550.20525656
Topological Polar Surface Area108 Ų
Heavy Atom Count40
Formal Charge0
Complexity925
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B5593-1Pluripotin
TRC-P632002-50MGPluripotin-d3
C18033Pluripotin (SC1)
sc-255607CSC1 (Pluripotin)

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