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UNC2025

CAT: 0013-GTR19168346-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168346-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC-2025 (MRX-6343) is a potent, orally bioavailable small molecule inhibitor targeting MER and FLT3 kinases with IC50 values of 0.74 nM and 0.8 nM, respectively. It demonstrates approximately 20-fold selectivity over Axl and Tyro3. This inhibitor is a valuable research tool for studying oncology, particularly in leukemia and solid tumor models, both in vitro and in vivo.
CAS Number
1429881-91-3
Product Name Alternative
Cluster of differentiation antigen 135, CD135, acute, cancer, AXL, inhibit, mrx-6313, Inhibitor, Mer, MERTK, leukemia, Fms like tyrosine kinase 3, FLT3, TAM Receptor, TAMReceptor, Tyro3, UNC2025, UNC-2025, UNC 2025
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.48% (May vary between batches)
Solubility
H2O:Insoluble; Ethanol:8 mg/mL (16.78 mM) ; DMSO:35.71 mg/mL (74.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.39 mM)
Smiles
CCCCNc1ncc2c (cn ([C@H]3CC[C@H] (O) CC3) c2n1) -c1ccc (CN2CCN (C) CC2) cc1
Molecular Formula
C28H40N6O
Molecular Weight
476.66
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

trans-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol

See also: Unc2025 (annotation moved to).

CAS Number1429881-91-3
PubChem CID73425588
IUPAC Name4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol
Molecular FormulaC28H40N6O
Molecular Weight476.7
XLogP4
Topological Polar Surface Area69.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count35
Formal Charge0
Complexity627
SMILES
CCCCNC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCN(CC5)C
InChI
InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)
InChIKey
MJSHVHLADKXCML-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of trans-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
CAS: 1429881-91-3
CID: 73425588
Formula: C28H40N6O
MW: 476.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight476.7
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass476.32635992
Monoisotopic Mass476.32635992
Topological Polar Surface Area69.5 Ų
Heavy Atom Count35
Formal Charge0
Complexity627
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B8016-25UNC2025
T39474-01UNC2025 hydrochloride
C12790-01UNC2025 HCl
HY-12344A-01UNC2025 (hydrochloride)
MBS3609399-01UNC2025 2HCl
T4419-01UNC2025 2HCl (1429881-91-3 (free base) )
MBS5750538UNC2025 2HCl (1429881-91-3(Free Base))

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