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UNC2250

CAT: 0013-GTR19173242-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173242-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC2250 is a potent and selective small molecule inhibitor of the Mer tyrosine kinase, exhibiting an IC50 of 1.7 nM. It is a valuable research tool for studying Mer signaling in oncology and immuno-oncology, with utility in both in vitro cellular assays and in vivo tumor model studies.
CAS Number
1493694-70-4
Product Name Alternative
Inhibit, Inhibitor, Mer, Axl, AXL, TAMReceptor, TAM Receptor, Tyro3, UNC2250, UNC-2250, UNC 2250
Field of Research
Signal Transduction
Purity
98.57% (May vary between batches)
Solubility
20% Cremophor EL:5 mg/mL (11.35 mM) ; DMSO:25 mg/mL (56.74 mM)
Smiles
CCCCNc1ncc (c (N[C@H]2CC[C@H] (O) CC2) n1) -c1ccc (CN2CCOCC2) cn1
Molecular Formula
C24H36N6O2
Molecular Weight
440.58
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(1R,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol
CAS Number1493694-70-4
PubChem CID73211763
IUPAC Name4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)-2-pyridinyl]pyrimidin-4-yl]amino]cyclohexan-1-ol
Molecular FormulaC24H36N6O2
Molecular Weight440.6
XLogP2.8
Topological Polar Surface Area95.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Heavy Atom Count32
Formal Charge0
Complexity527
SMILES
CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C3=NC=C(C=C3)CN4CCOCC4
InChI
InChI=1S/C24H36N6O2/c1-2-3-10-25-24-27-16-21(23(29-24)28-19-5-7-20(31)8-6-19)22-9-4-18(15-26-22)17-30-11-13-32-14-12-30/h4,9,15-16,19-20,31H,2-3,5-8,10-14,17H2,1H3,(H2,25,27,28,29)
InChIKey
HSYSSKFCQHXOBP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of (1R,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol
CAS: 1493694-70-4
CID: 73211763
Formula: C24H36N6O2
MW: 440.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.6
XLogP32.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass440.28997441
Monoisotopic Mass440.28997441
Topological Polar Surface Area95.4 Ų
Heavy Atom Count32
Formal Charge0
Complexity527
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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