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DRB

CAT: 0013-GTR19167395-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167395-01Size:10 mg
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Description
DRB is a nucleoside analog that acts as a potent inhibitor of multiple carboxyl-terminal domain (CTD) kinases, notably casein kinase II, with IC50 values ranging from 4 to 10 μM. It is widely used in biochemical and cellular research to study transcription regulation, RNA polymerase II activity, and cell cycle progression in both in vitro and in vivo experimental models.
CAS Number
53-85-0
Product Name Alternative
5,6-Dichlorobenzimidazole riboside; NSC 401575
Field of Research
Cell Biology, Infectious Disease & Virology, Protein Biochemistry
Purity
>98%
Bioactivity
Transcription inhibitor; CK2 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 20 mg/ml)
Smiles
C1=C2C (=CC (=C1Cl) Cl) N (C=N2) [C@H]3[C@@H] ([C@@H] ([C@H] (O3) CO) O) O
Molecular Formula
C12H12Cl2N2O4
Molecular Weight
319.14
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

Chemical Information

5,6-Dichloro-1-(beta-D-ribofuranosyl)benzimidazole

An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.

CAS Number53-85-0
PubChem CID5894
IUPAC Name(2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Molecular FormulaC12H12Cl2N2O4
Molecular Weight319.14
XLogP1.1
Topological Polar Surface Area87.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity364
SMILES
C1=C2C(=CC(=C1Cl)Cl)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
InChI
InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChIKey
XHSQDZXAVJRBMX-DDHJBXDOSA-N
Chemical Structure
2D Structure
2D structure of 5,6-Dichloro-1-(beta-D-ribofuranosyl)benzimidazole
CAS: 53-85-0
CID: 5894
Formula: C12H12Cl2N2O4
MW: 319.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight319.14
XLogP31.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass318.0174123
Monoisotopic Mass318.0174123
Topological Polar Surface Area87.7 Ų
Heavy Atom Count20
Formal Charge0
Complexity364
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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