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PT-2385

CAT: 0013-GTR19167344-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167344-02Size:2 mg
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Description
PT-2385 is a potent and selective small molecule inhibitor of HIF-2α, exhibiting a dissociation constant (Kd) below 50 nM. It is a valuable research tool for studying hypoxia signaling pathways in both cellular and animal models, particularly in oncology and renal physiology research.
CAS Number
1672665-49-4
Product Name Alternative
Inhibit, Inhibitor, Hypoxia-inducible factors, HIFProlylHydroxylase, HIFs, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF-PH, HIF-2α, PT 2385, PT2385, PT-2385
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research
Purity
98.69% (May vary between batches)
Solubility
DMSO:270 mg/mL (704.34 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.22 mM)
Smiles
CS (=O) (=O) c1ccc (Oc2cc (F) cc (c2) C#N) c2CC (F) (F) [C@@H] (O) c12
Molecular Formula
C17H12F3NO4S
Molecular Weight
383.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PT-2385

PT-2385 is a selective HIF-2a inhibitor with a Ki of less than 50 nM.

CAS Number1672665-49-4
PubChem CID91754484
IUPAC Name3-[[(1S)-2,2-difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile
Molecular FormulaC17H12F3NO4S
Molecular Weight383.3
XLogP2.4
Topological Polar Surface Area95.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity686
SMILES
CS(=O)(=O)C1=C2[C@@H](C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O
InChI
InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/m0/s1
InChIKey
ONBSHRSJOPSEGS-INIZCTEOSA-N
Chemical Structure
2D Structure
2D structure of PT-2385
CAS: 1672665-49-4
CID: 91754484
Formula: C17H12F3NO4S
MW: 383.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight383.3
XLogP32.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass383.04391352
Monoisotopic Mass383.04391352
Topological Polar Surface Area95.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity686
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BA7793-1PT-2385
A21561-1PT-2385 1mg
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A21561-25PT-2385 25mg
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