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AES-350

CAT: 0013-GTR19166901-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166901-01Size:1 mg
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Description
AES-350 is a potent, orally bioavailable HDAC6 inhibitor with high selectivity. It induces apoptosis in acute myeloid leukemia (AML) cells in vitro and shows potential for in vivo research, making it a valuable tool for oncology and epigenetics studies.
CAS Number
847249-57-4
Product Name Alternative
Histone deacetylases, Inhibitor, HDAC, HDAC11, HDAC3, HDAC6, MV4-11, inhibit, Apoptosis, AML, acute myeloid leukemia, AES 350, AES350, AES-350
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
98.82% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.81 mM) ; DMSO:100 mg/mL (320.14 mM)
Smiles
CC (C) (C) c1ccc (cc1) C (=O) Nc1ccc (cc1) C (=O) NO
Molecular Formula
C18H20N2O3
Molecular Weight
312.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tert-butylbenzamido hydroxylbenzamide
CAS Number847249-57-4
PubChem CID11688197
IUPAC Name4-tert-butyl-N-[4-(hydroxycarbamoyl)phenyl]benzamide
Molecular FormulaC18H20N2O3
Molecular Weight312.4
XLogP3.2
Topological Polar Surface Area78.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity414
SMILES
CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO
InChI
InChI=1S/C18H20N2O3/c1-18(2,3)14-8-4-12(5-9-14)16(21)19-15-10-6-13(7-11-15)17(22)20-23/h4-11,23H,1-3H3,(H,19,21)(H,20,22)
InChIKey
FMOQHLZNJFXULZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tert-butylbenzamido hydroxylbenzamide
CAS: 847249-57-4
CID: 11688197
Formula: C18H20N2O3
MW: 312.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight312.4
XLogP33.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass312.14739250
Monoisotopic Mass312.14739250
Topological Polar Surface Area78.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity414
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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