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Paltusotine

CAT: 0013-GTR19166833-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166833-04Size:25 mg
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Description
Paltusotine is an orally bioavailable, nonpeptide small molecule agonist of the somatostatin type 2 (SST2) receptor. It is used in research to investigate the pharmacological control of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels, relevant for acromegaly studies in both in vitro and in vivo models.
CAS Number
2172870-89-0
Product Name Alternative
CRN 00808, CRN00808, CRN-00808, Inhibitor, IGF-1, inhibit, Paltusotine, orally, SSTRs, SSTR, SST2, Somatostatin Receptor
Field of Research
Pharmacology & Drug Discovery
Purity
99.77% (May vary between batches)
Solubility
DMSO:20 mg/mL (43.81 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.38 mM)
Smiles
NC1CCN (CC1) c1c (cnc2ccc (cc12) -c1cccc (C#N) c1O) -c1cc (F) cc (F) c1
Molecular Formula
C27H22F2N4O
Molecular Weight
456.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Paltusotine

Paltusotine is a selective somatostatin receptor agonist: It mimics the biological actions of endogenous somatostatin, which activates the somatostatin 2 receptor (SST2) to block the secretion of growth hormone (GH) and decreases the production of growth-promoting insulin-like growth factor 1 (IGF-1). Paltusotine exhibits high affinity and selectivity towards SST2. Paltusotine was approved by the FDA on September 25, 2025 for the treatment of acromegaly in adults.

CAS Number2172870-89-0
PubChem CID134168328
IUPAC Name3-[4-(4-aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile
Molecular FormulaC27H22F2N4O
Molecular Weight456.5
XLogP5.3
Topological Polar Surface Area86.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count34
Formal Charge0
Complexity727
SMILES
C1CN(CCC1N)C2=C3C=C(C=CC3=NC=C2C4=CC(=CC(=C4)F)F)C5=CC=CC(=C5O)C#N
InChI
InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2
InChIKey
GHILNKWBALQPDP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Paltusotine
CAS: 2172870-89-0
CID: 134168328
Formula: C27H22F2N4O
MW: 456.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.5
XLogP35.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass456.17616766
Monoisotopic Mass456.17616766
Topological Polar Surface Area86.2 Ų
Heavy Atom Count34
Formal Charge0
Complexity727
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA5816-25Paltusotine
HY-109155APaltusotine (hydrochloride)
T69836-01Paltusotine HCl

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