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IC 86621

CAT: 0013-GTR19166778-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166778-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IC 86621 is a potent, selective, and reversible ATP-competitive inhibitor of DNA-PK, exhibiting an IC50 of 120 nM. It disrupts DNA double-strand break repair with an EC50 of 68 μM in cellular assays, enhancing the antitumor effects of DNA-damaging agents in cancer research models, both in vitro and in vivo.
CAS Number
404009-40-1
Product Name Alternative
DNA-dependent protein kinase, DNAPK, DNA-PK, DSB, Buchwald-Hartwig amination, ATP, Apoptosis, antitumor, Fries rearrangement, Inhibitor, IC 86621, IC86621, IC-86621, inhibit
Field of Research
Cell Biology, Molecular Biology, Signal Transduction
Purity
99.33% (May vary between batches)
Solubility
DMSO:50 mg/mL (225.99 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.04 mM)
Smiles
CC (=O) c1ccc (cc1O) N1CCOCC1
Molecular Formula
C12H15NO3
Molecular Weight
221.25
Storage Conditions
-20°C
Notes
For research use only.

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MBS3604382-01IC 86621

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