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K-975

CAT: 0013-GTR19166683-05Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166683-05Size:1 mg
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Description
K-975 is a potent and selective oral TEAD inhibitor that disrupts the TEAD-YAP1/TAZ protein-protein interaction. It is used in cancer research, particularly for mesothelioma and other malignancies driven by Hippo pathway dysregulation, and has demonstrated efficacy in both cellular assays and in vivo models.
CAS Number
2563855-03-6
Product Name Alternative
YAP, TAZ, TEAD, YAP1/TAZ, TEAD, Yes-associated protein, YAP1, pleural, mesothelioma, K975, K-975, K 975, inhibit, malignant, Inhibitor, Cys359, cancer, antitumor
Field of Research
Stem Cell & Developmental Biology
Purity
99.43% (May vary between batches)
Solubility
DMSO:140 mg/mL (486.55 mM)
Smiles
Cc1ccc (NC (=O) C=C) cc1Oc1ccc (Cl) cc1
Molecular Formula
C16H14ClNO2
Molecular Weight
287.74
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(3-(4-Chlorophenoxy)-4-methylphenyl)acrylamide
CAS Number2563855-03-6
PubChem CID155353714
IUPAC NameN-[3-(4-chlorophenoxy)-4-methylphenyl]prop-2-enamide
Molecular FormulaC16H14ClNO2
Molecular Weight287.74
XLogP4.2
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity339
SMILES
CC1=C(C=C(C=C1)NC(=O)C=C)OC2=CC=C(C=C2)Cl
InChI
InChI=1S/C16H14ClNO2/c1-3-16(19)18-13-7-4-11(2)15(10-13)20-14-8-5-12(17)6-9-14/h3-10H,1H2,2H3,(H,18,19)
InChIKey
KPXAHQSIROUBPH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-(4-Chlorophenoxy)-4-methylphenyl)acrylamide
CAS: 2563855-03-6
CID: 155353714
Formula: C16H14ClNO2
MW: 287.74
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.74
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass287.0713064
Monoisotopic Mass287.0713064
Topological Polar Surface Area38.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity339
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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