Products for Research Use Only
RegisterLogin

PF-05089771

CAT: 0013-GTR19166541-02Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19166541-02Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PF 05089771 is a potent and selective Nav1.7 voltage-gated sodium channel inhibitor (IC50 = 11 nM) that binds to the voltage-sensor domain IV. Its blocking action exhibits a slow, depolarization- and concentration-dependent onset. This compound is a valuable research tool for investigating pain pathways in both in vitro and in vivo models.
CAS Number
1235403-62-9
Product Name Alternative
PF771
Field of Research
Neuroscience
Purity
>98%
Bioactivity
Nav1.7 inhibitor (selective)
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
Nc1n[nH]cc1-c1cc (Cl) ccc1Oc1cc (F) c (cc1Cl) S (=O) (=O) Nc1cscn1
Molecular Formula
C18H12Cl2FN5O3S2
Molecular Weight
500.3
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-[2- (5-Amino-1H-pyrazol-4-yl) -4-chlorophenoxy]-5-chloro-2-fluoro-N- (1,3-thiazol-4-yl) benzenesulfonamide

Chemical Information

Pf-05089771

PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee).

CAS Number1235403-62-9
PubChem CID46840946
IUPAC Name4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide
Molecular FormulaC18H12Cl2FN5O3S2
Molecular Weight500.4
XLogP4.3
Topological Polar Surface Area160
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count31
Formal Charge0
Complexity721
SMILES
C1=CC(=C(C=C1Cl)C2=C(NN=C2)N)OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=CSC=N4)F
InChI
InChI=1S/C18H12Cl2FN5O3S2/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17/h1-8,26H,(H3,22,24,25)
InChIKey
ZYSCOUXLBXGGIM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pf-05089771
CAS: 1235403-62-9
CID: 46840946
Formula: C18H12Cl2FN5O3S2
MW: 500.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight500.4
XLogP34.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass498.9742652
Monoisotopic Mass498.9742652
Topological Polar Surface Area160 Ų
Heavy Atom Count31
Formal Charge0
Complexity721
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19224314-01PF-06745013
GTR19222974-01PF-06764427
GTR19218956-01PF-07208254
GTR19218556-01PF-07059013
GTR19213053-01PF-17
GTR19212475-01PF-06455943
GTR19211449-01PF-446687
GTR19210318-01PF-4211
GTR19209610-01PF-06658607
GTR19209586-01PF-303

Alternative Products

CatalogName
MBS3841609-01PF-05089771
HY-12883-01PF 05089771
526590PF-05089771 Tosylate
A16365-10PF-05089771 10mg
A16365-5PF-05089771 5mg
T7502-01PF 05089771 tosylate
A16365-100PF-05089771 100mg
HY-12883B-01PF 05089771 (tosylate)
A16365-50PF-05089771 50mg
A16365-25PF-05089771 25mg

Popular Products