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COH-SR4

CAT: 0013-GTR19165906-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19165906-01Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COH-SR4 is a mitochondrial oxidative phosphorylation uncoupler that inhibits hepatocellular carcinoma cell proliferation by modulating the AMPK-mTOR signaling pathway. It serves as a research tool for studying cancer metabolism and has demonstrated anti-proliferative effects in in vitro models like HepG2 cells.
CAS Number
73439-19-7
Product Name Alternative
Leukemia, melanoma, Inhibitor, lung, inhibit, kinase, Mitochondria uncoupler SR4, AMP-activated protein kinase, anti-proliferative, AMP-activated, AMPK, anticancer, anti-adipogenic, cancers, breast, COH SR4, COHSR4, COH-SR4, COH-SR-4, COH-SR4 (Mitochondria uncoupler SR4), protein
Field of Research
Epigenetics & Chromatin, Signal Transduction
Purity
98.96% (May vary between batches)
Solubility
DMSO:4 mg/mL (11.43 mM)
Smiles
Clc1cc (Cl) cc (NC (=O) Nc2cc (Cl) cc (Cl) c2) c1
Molecular Formula
C13H8Cl4N2O
Molecular Weight
350.03
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1,3-Bis(3,5-dichlorophenyl)urea

COH - City of Hope; has antineoplastic activity

CAS Number73439-19-7
PubChem CID595311
IUPAC Name1,3-bis(3,5-dichlorophenyl)urea
Molecular FormulaC13H8Cl4N2O
Molecular Weight350.0
XLogP5
Topological Polar Surface Area41.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity294
SMILES
C1=C(C=C(C=C1Cl)Cl)NC(=O)NC2=CC(=CC(=C2)Cl)Cl
InChI
InChI=1S/C13H8Cl4N2O/c14-7-1-8(15)4-11(3-7)18-13(20)19-12-5-9(16)2-10(17)6-12/h1-6H,(H2,18,19,20)
InChIKey
VKVJIWVUYNTBEZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,3-Bis(3,5-dichlorophenyl)urea
CAS: 73439-19-7
CID: 595311
Formula: C13H8Cl4N2O
MW: 350.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight350.0
XLogP35
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass349.936124
Monoisotopic Mass347.939074
Topological Polar Surface Area41.1 Ų
Heavy Atom Count20
Formal Charge0
Complexity294
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
E0795COH-SR4
MBS5759508COH-SR4 (Mitochondria uncoupler SR4)
MBS3612635-01COH-SR4(Mitochondria uncoupler SR4)
S0283-5mgCOH-29
OM637065-01Histone H2A (hydroxyl Y39) [SR4-17] Antibody
OM637064-01Histone H2A (acetyl K9) [SR4-15] Antibody
ET1602-34Histone H2A (acetyl K9) Recombinant Rabbit Monoclonal Antibody [SR4-15]
IRBAHUCDH1COH3C100ULRabbit Anti Human CDH1 Monoclonal Clone COH-3 100UL
IRBAHUCDH1COH3C100ugRabbit Anti Human CDH1 Monoclonal Clone COH-3 100ug
ET1602-35Histone H2A (hydroxyl Y39) Recombinant Rabbit Monoclonal Antibody [SR4-17]

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