Products for Research Use Only
RegisterLogin

DS-1205

CAT: 0013-GTR19165783-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19165783-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DS-1205 is a highly potent and selective AXL kinase inhibitor (IC50 = 1.3 nM), with additional activity against MER, MET, and TRKA kinases. This small molecule has demonstrated efficacy in suppressing cell migration in vitro and impeding tumor growth in animal models, supporting its research use in oncology and metastasis studies.
CAS Number
1855860-24-0
Product Name Alternative
C-Met/HGFR, DS 1205, DS1205, DS-1205, DS-1205b, AXL, Axl, Inhibitor, Mer, NIH3T3, MET, migration, kinase, inhibit, Tropomyosin related kinase receptor, TRKA, Trk Receptor, Tyro3, tumor, TAM Receptor, TAMReceptor
Field of Research
Signal Transduction
Purity
99.28% (May vary between batches)
Solubility
DMSO:45 mg/mL (61.16 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.72 mM)
Smiles
COc1cc (ccc1OC[C@H]1COCCO1) -c1cnc (N) c (c1) -c1ccc (NC (=O) c2cn (CC3CCOCC3) cc (-c3ccc (C) cn3) c2=O) cc1F
Molecular Formula
C41H42FN5O7
Molecular Weight
735.8
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(R)-N-(4-(5-(4-((1,4-Dioxan-2-yl)methoxy)-3-methoxyphenyl)-2-aminopyridin-3-yl)-3-fluorophenyl)-5-methyl-4'-oxo-1'-((tetrahydro-2H-pyran-4-yl)methyl)-1',4'-dihydro-[2,3'-bipyridine]-5'-carboxamide
CAS Number1855860-24-0
PubChem CID129110632
IUPAC NameN-[4-[2-amino-5-[4-[[(2R)-1,4-dioxan-2-yl]methoxy]-3-methoxyphenyl]-3-pyridinyl]-3-fluorophenyl]-5-(5-methyl-2-pyridinyl)-1-(oxan-4-ylmethyl)-4-oxopyridine-3-carboxamide
Molecular FormulaC41H42FN5O7
Molecular Weight735.8
XLogP4.3
Topological Polar Surface Area147
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count11
Heavy Atom Count54
Formal Charge0
Complexity1330
SMILES
CC1=CN=C(C=C1)C2=CN(C=C(C2=O)C(=O)NC3=CC(=C(C=C3)C4=C(N=CC(=C4)C5=CC(=C(C=C5)OC[C@H]6COCCO6)OC)N)F)CC7CCOCC7
InChI
InChI=1S/C41H42FN5O7/c1-25-3-7-36(44-18-25)33-21-47(20-26-9-11-51-12-10-26)22-34(39(33)48)41(49)46-29-5-6-31(35(42)17-29)32-15-28(19-45-40(32)43)27-4-8-37(38(16-27)50-2)54-24-30-23-52-13-14-53-30/h3-8,15-19,21-22,26,30H,9-14,20,23-24H2,1-2H3,(H2,43,45)(H,46,49)/t30-/m1/s1
InChIKey
ZOEILZXFYPPMTR-SSEXGKCCSA-N
Chemical Structure
2D Structure
2D structure of (R)-N-(4-(5-(4-((1,4-Dioxan-2-yl)methoxy)-3-methoxyphenyl)-2-aminopyridin-3-yl)-3-fluorophenyl)-5-methyl-4'-oxo-1'-((tetrahydro-2H-pyran-4-yl)methyl)-1',4'-dihydro-[2,3'-bipyridine]-5'-carboxamide
CAS: 1855860-24-0
CID: 129110632
Formula: C41H42FN5O7
MW: 735.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight735.8
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count11
Exact Mass735.30682686
Monoisotopic Mass735.30682686
Topological Polar Surface Area147 Ų
Heavy Atom Count54
Formal Charge0
Complexity1330
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19209599-01ZBH-1205
GTR19165769-01CPI-1205
GTR19212088-01DS-9300
GTR19197736-01DS-8587
GTR19238269-01DS-1093a
GTR19171094-01DS-7423
GTR19167436-01DS-1001b
GTR19257745-01DS-1150b
GTR19211820-01DS-2969
GTR19209372-01DS 4574

Alternative Products

CatalogName
MBS3617119-01DS-1205
HY-P990613-01LIV-1205 (CBA-1205)
B7819-10CPI-1205
256870-01TCS 1205
T70380-01ZBH-1205
T9901A-064-01LIV-1205

Popular Products