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UMB298

CAT: 0013-GTR19165727-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165727-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UMB298 is a potent and selective small-molecule inhibitor targeting the CBP/P300 bromodomains. It exhibits significantly lower activity against BRD4 (IC50 = 5193 nM) . This compound is a valuable chemical probe for epigenetic research, facilitating the study of CBP/P300 function in transcriptional regulation in both cellular and biochemical assays.
CAS Number
2266569-73-5
Product Name Alternative
CBP30, BRD4, bromodomain, inhibit, Inhibitor, MOLM13, EpigeneticReaderDomain, Epigenetic Reader Domain, selective, potent, UMB298, UMB-298, UMB 298
Field of Research
Epigenetics & Chromatin
Purity
99.76% (May vary between batches)
Solubility
DMSO:20 mg/mL (41.75 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.18 mM)
Smiles
COc1ccc (CCc2nc3cc (ccn3c2NC2CCCCC2) -c2c (C) noc2C) cc1Cl
Molecular Formula
C27H31ClN4O2
Molecular Weight
479.01
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-(3-Chloro-4-methoxyphenethyl)-N-cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)imidazo[1,2-a]pyridin-3-amine
CAS Number2266569-73-5
PubChem CID137409212
IUPAC Name2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine
Molecular FormulaC27H31ClN4O2
Molecular Weight479.0
XLogP7.6
Topological Polar Surface Area64.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity650
SMILES
CC1=C(C(=NO1)C)C2=CC3=NC(=C(N3C=C2)NC4CCCCC4)CCC5=CC(=C(C=C5)OC)Cl
InChI
InChI=1S/C27H31ClN4O2/c1-17-26(18(2)34-31-17)20-13-14-32-25(16-20)30-23(27(32)29-21-7-5-4-6-8-21)11-9-19-10-12-24(33-3)22(28)15-19/h10,12-16,21,29H,4-9,11H2,1-3H3
InChIKey
NZXSWCLCRDCHGN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(3-Chloro-4-methoxyphenethyl)-N-cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)imidazo[1,2-a]pyridin-3-amine
CAS: 2266569-73-5
CID: 137409212
Formula: C27H31ClN4O2
MW: 479.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight479.0
XLogP37.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass478.2135539
Monoisotopic Mass478.2135539
Topological Polar Surface Area64.6 Ų
Heavy Atom Count34
Formal Charge0
Complexity650
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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